# Restoring prearthritic alignment improves joint perception in medial unicompartmental knee arthroplasty

**Authors:** Zhaolun Wang, Wang Deng, Yixin Zhou, Yong Huang, Shaoyi Guo, Yunfeng Zhang

PMC · DOI: 10.1002/jeo2.70389 · 2025-08-05

## TL;DR

Restoring prearthritic alignment during knee surgery improves joint perception and function, particularly in patients with constitutional varus alignment.

## Contribution

This study demonstrates that restoring prearthritic alignment in UKA leads to better joint perception and function compared to traditional neutral alignment.

## Key findings

- Patients with restored prearthritic alignment had significantly higher FJS-12, OKS, and WOMAC scores.
- A 1-degree deviation from prearthritic alignment decreased the probability of achieving a 'forgotten joint' by 21%.
- Prearthritic alignment was associated with better outcomes in patients with constitutional varus alignment.

## Abstract

This study aims to investigate whether restoring prearthritic alignment improves joint perception in medial unicompartmental knee arthroplasty (UKA).

This retrospective cohort study analysed 244 patients who underwent nonrobotic‐assisted medial fixed‐bearing UKA between 2015 and 2018 with a minimum 2‐year follow‐up. Patients were categorised into prearthritic and nonprearthritic alignment groups based on the difference between their postoperative alignment and prearthritic hip‐knee‐ankle angle. Postoperative outcomes, including the Forgotten Joint Score (FJS‐12), Oxford Knee Score (OKS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS) and University of California Los Angeles (UCLA) activity score were compared between the groups. Additional analysis was performed in a subgroup of patients with constitutional varus alignment (CPAK types I, IV and VII). Multivariable logistic regression was used to identify predictors of achieving a forgotten joint.

Patients with restored prearthritic alignment had significantly higher FJS‐12 (71.9 vs. 63.4, p = 0.005), OKS (40.7 vs. 38.1, p = 0.003) and WOMAC (91.2 vs. 88.1, p = 0.017) scores compared to those with nonprearthritic alignment. In the constitutional varus subgroup, prearthritic alignment was associated with higher FJS‐12, UCLA, OKS and KOOS ADL scores. The prearthritic alignment group also had a higher likelihood of achieving the ‘forgotten joint’ state. A 1‐degree deviation from prearthritic alignment was associated with a 21% decrease in the probability of achieving a forgotten joint.

Restoring prearthritic alignment in UKA is associated with improved postoperative joint perception and function, especially in patients with constitutional varus alignment. This personalised alignment approach may lead to better outcomes than the traditional goal of neutral alignment. Further research with a longer follow‐up period is required to validate these findings and explore their impact on prosthesis survival.

Level II.

## Full-text entities

- **Diseases:** CPAK (MESH:C537786), infections (MESH:D007239), CCI (MESH:C566784), varus (MESH:D060905), JLO (MESH:C537736), OA (MESH:D010003), Comorbidity (MESH:D004194), valgus (MESH:D060906), flexion deformity (MESH:D009140), Knee Injury and Osteoarthritis (MESH:D020370), PASS (MESH:D012816), UKA (MESH:D007718), blood loss (MESH:D016063)
- **Chemicals:** MPTA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** FJS-12 — Mus musculus (Mouse), Hybridoma (CVCL_J992)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12322694/full.md

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Source: https://tomesphere.com/paper/PMC12322694