ZIF-8-loaded decellularized porcine annulus fibrosus bioadhesive enhances rotator cuff tendon-to-bone healing in a rat model
Xiping Jiang, Hui Xu, Xinyue Sun, Xuefan Yang, Yuxuan Xia, Wen Xue, Yaohua He
TL;DR
A new bioadhesive made from pig tissue and ZIF-8 improves rotator cuff healing in rats by boosting fibrocartilage and bone regeneration.
Contribution
A novel ZIF-8-loaded bioadhesive derived from decellularized porcine annulus fibrosus extracellular matrix is proposed for rotator cuff healing.
Findings
The ST/dECM/ZIF-8 group enhanced chondrogenic and osteogenic differentiation of BMSCs compared to other groups.
In vivo, the ST/dECM/ZIF-8 hydrogel reduced inflammation and promoted fibrocartilage and bone regeneration.
Adhesive-treated groups showed significantly higher biomechanical performance compared to untreated controls.
Abstract
The high rate of retear following rotator cuff repair is largely attributed to the absence of a fibrocartilage layer and limited bone regeneration capacity. We aim to evaluate a bioadhesive derived from decellularized porcine annulus fibrosus extracellular matrix, loaded with zeolitic imidazolate framework-8 (ZIF-8), and to promote rotator cuff tendon–bone healing. Three adhesive formulations were developed: (1) silk fibroin/tannic acid (ST group), (2) ST combined with decellularized porcine annulus fibrosus extracellular matrix (ST/dECM group), and (3) ST/dECM supplemented with ZIF-8 (ST/dECM/ZIF-8 group). Optimal component ratios were determined using lap shear strength testing. The microstructure, Fourier transform infrared (FTIR) spectra, swelling behavior, and degradation properties of the materials were characterized. In vitro studies assessed the adhesives’ effects on…
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Taxonomy
TopicsShoulder Injury and Treatment · Tendon Structure and Treatment · Surgical Sutures and Adhesives