# Management Strategies for Seminal Vesicle Cysts in Zinner Syndrome: Insights From Two Cases

**Authors:** Fadhel Yusuf, Abdulla Husain, Zuhair Sikafi, Salam Alhasani, Mudhar N Hasan

PMC · DOI: 10.7759/cureus.87348 · Cureus · 2025-07-05

## TL;DR

This paper discusses two different treatment approaches for a rare condition called Zinner syndrome, showing that personalized care and minimally invasive surgery can lead to good outcomes.

## Contribution

The paper contributes two case studies demonstrating effective conservative and surgical management strategies for Zinner syndrome.

## Key findings

- Conservative observation successfully managed a patient with mild and stable Zinner syndrome symptoms.
- Laparoscopic robotic-assisted vesiculectomy improved symptoms in a patient after failed medical therapy.
- Minimally invasive surgery is a safe and effective option for selected symptomatic Zinner syndrome patients.

## Abstract

Zinner syndrome is a rare congenital malformation that affects the male genitourinary tract, characterized by a triad of unilateral renal agenesis, seminal vesicle cysts, and ejaculatory duct obstruction, and typically presents during the third or fourth decade of life. In this report, we present two cases illustrating distinct management pathways. One patient, with mild and stable symptoms, was successfully managed with conservative observation. The second patient, following failed medical therapy, underwent a successful laparoscopic robotic-assisted vesiculectomy with significant symptom improvement. These cases highlight the clinical variability associated with Zinner syndrome and reinforce the importance of a tailored, patient-specific approach to management. They also contribute to the growing literature supporting minimally invasive surgical techniques as a safe and effective option for selected symptomatic patients with Zinner syndrome, offering favorable outcomes with reduced morbidity.

## Linked entities

- **Diseases:** Zinner syndrome (MONDO:0100109)

## Full-text entities

- **Diseases:** Zinner Syndrome (MESH:D013577), renal agenesis (MESH:C536482), ejaculatory duct obstruction (MESH:D002779), Seminal Vesicle Cysts (MESH:C537244), congenital malformation (OMIM:163000)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12322186/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12322186/full.md

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Source: https://tomesphere.com/paper/PMC12322186