# New trends and hotspots in sepsis-related protein post-translational modification: a bibliometric and visual analysis

## TL;DR

This paper analyzes global research trends in sepsis-related protein modifications using bibliometric tools to identify key areas and institutions driving progress.

## Contribution

The study provides the first comprehensive bibliometric analysis of sepsis-related post-translational modification research from 2005 to 2024.

## Key findings

- China leads sepsis-related PTM research with 48.68% of publications.
- Phosphorylation, ubiquitination, and methylation are current research hotspots.
- Emerging trends include sepsis-associated acute kidney injury and mitochondrial dysfunction.

## Abstract

Sepsis is a clinical syndrome characterized by high morbidity and mortality rates, posing a severe threat to human health. Its pathophysiology is complex, involving multiple physiological and pathological processes. Protein post-translational modification (PTM) play a pivotal role in the pathophysiology of sepsis by regulating inflammation, immune responses, and organ dysfunction. In recent years, there has been a growing focus on the association between sepsis and PTM; however, a comprehensive and systematic analysis of the current research status and development trends in this field is still lacking.

This study analyzed literature from the Web of Science Core Collection published between 2005 and 2024. CiteSpace, VOSviewer, and Excel facilitated the bibliometric analysis, visualizing publication trends, contributions across countries/regions and institutions, journal distributions, author collaboration networks, and keyword clusters.

A total of 1705 articles were included, originating from 58 countries/regions. The annual publication volume showed exponential growth (R2 = 0.9662), with China leading the way (48.68%), followed by the United States (29.27%). Shanghai Jiao Tong University emerged as a high-yield institution (n = 51), while the University of Pittsburgh demonstrated the highest citation impact (with an average of 109.87 citations per article). Prominent journals featuring these articles include Shock (n = 77) and the Journal of Immunology (with an average citation of 65.75 times per article). Research hotspots were centered around phosphorylation, ubiquitination, and methylation, with emerging trends such as sepsis-associated acute kidney injury (SA-AKI), autophagy, and mitochondrial dysfunction.

Research on the sepsis-related PTM is flourishing. This study systematically reveals the research dynamics and core trends in this field.

Flowchart illustrating the analysis of sepsis-related post-translational modifications (PTM) using bibliometric tools. The process starts with a search strategy in WOSCC from 2005 to 2025, yielding 3,031 results, filtered to 1,705. The data undergoes bibliometric analysis through Excel 2021, VOSviewer, and CiteSpace, showcasing charts, network maps, and keyword analysis. The final goal is to assess the current status and prospects of sepsis-related PTMs.