# Case Report: Giant sacrococcygeal teratoma in neonates—a report of three cases

**Authors:** Letu Wu Ri Ni, Yimin Nong, Jinben Wang, Xiujian Liang, Baoxin Zhang, Zhenying Lin

PMC · DOI: 10.3389/fped.2025.1600920 · Frontiers in Pediatrics · 2025-07-22

## TL;DR

This paper reports three cases of large neonatal tumors near the spine and highlights the importance of careful management and teamwork to improve outcomes.

## Contribution

The novelty lies in presenting three rare cases of giant sacrococcygeal teratomas and emphasizing the need for contingency planning and interdisciplinary care.

## Key findings

- Giant sacrococcygeal teratomas can lead to severe complications like heart failure and coagulation issues.
- Interdisciplinary collaboration is crucial for managing these tumors and minimizing complications.
- Comprehensive contingency plans are necessary to improve neonatal survival rates.

## Abstract

Although most cases of neonatal sacrococcygeal teratoma are benign, some can grow into very large lesions, potentially causing high-output heart failure, massive bleeding, disseminated intravascular coagulation, and even fatal outcomes. We report three cases of giant sacrococcygeal teratomas, detailing their diagnostic and therapeutic management. We emphasize that clinicians should be prepared with comprehensive contingency plans and that interdisciplinary collaboration is essential to enhance patient survival rates and minimize potential complications.

## Linked entities

- **Diseases:** sacrococcygeal teratoma (MONDO:0042727), high-output heart failure (MONDO:0005253), disseminated intravascular coagulation (MONDO:0001243)

## Full-text entities

- **Genes:** AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}
- **Diseases:** hypothermia (MESH:D007035), SCT (MESH:D013724), tenderness (MESH:D063806), germ cell tumor (MESH:D009373), pain (MESH:D010146), apnea (MESH:D001049), polyhydramnios (MESH:D006831), respiratory distress (MESH:D012128), preterm labor (MESH:D007752), vaginal bleeding (MESH:D014592), infection (MESH:D007239), tumor (MESH:D009369), hydrops (MESH:D004487), fetal hydrops (MESH:D015160), mental illness (MESH:D001523), blood loss (MESH:D016063), cyanosis (MESH:D003490), disseminated intravascular coagulation (MESH:D004211), hypotonia (MESH:D009123), sacrococcygeal tumors (MESH:C537225), mature (MESH:D003924), tumor rupture (MESH:D012421), rectal or bladder dysfunction (MESH:D012002), cardiac failure (MESH:D006333), postoperative pain (MESH:D010149), XL (MESH:D000080345), bladder dysfunction (MESH:D001745), bleeding (MESH:D006470), preterm delivery (MESH:D047928), congenital megacolon (MESH:D006627)
- **Chemicals:** dexamethasone (MESH:D003907), Fentanyl (MESH:D005283), magnesium sulfate (MESH:D008278)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12321759/full.md

## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC12321759/full.md

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Source: https://tomesphere.com/paper/PMC12321759