# Renal epidermoid cyst mimicking renal tuberculous abscess: a case report

**Authors:** Jian Gao, Huijiu Luo, Han Zhu, Zhengdao Liu, Mingzhou Li, Yuzhu Chen, Shiyu Wang, Chao Zhou, Zhenhao Li, Guobiao Liang, Shulian Chen

PMC · DOI: 10.3389/fmed.2025.1632764 · Frontiers in Medicine · 2025-07-22

## TL;DR

A rare case of a kidney cyst mistaken for a tuberculosis abscess is reported, emphasizing the need for accurate diagnosis to avoid unnecessary treatment.

## Contribution

This case report adds to the limited global literature on renal epidermoid cysts and highlights diagnostic challenges and management strategies.

## Key findings

- Renal epidermoid cysts can mimic tuberculous abscesses clinically and radiologically.
- Histopathological confirmation is crucial for accurate diagnosis and avoiding unnecessary anti-tuberculosis therapy.
- Postoperative complications like renal artery pseudoaneurysm can occur and require interventional management.

## Abstract

Renal epidermoid cysts (RECs) are exceedingly rare benign cystic lesions, with only 15 histologically confirmed cases reported worldwide to date. Due to their non-specific clinical and radiological features, they are often misdiagnosed preoperatively as infectious or neoplastic conditions. Here, we report a 25-year-old man in whom a complex renal cyst was incidentally identified during a routine health examination. Retrospectively, the patient reported mild urinary frequency and low-grade fever. Imaging suggested a non-enhancing heterogeneous cyst in the lower pole of the right kidney. Laparoscopic partial nephrectomy was performed, revealing abundant yellow-white caseating material intraoperatively, prompting empirical anti-tuberculosis therapy in the context of regional endemicity. However, histopathological analysis confirmed a diagnosis of RECs, and anti-tuberculous treatment was subsequently withdrawn. On postoperative day 5, the patient developed gross hematuria due to a renal artery pseudoaneurysm, which was successfully managed with selective arterial embolization. This case highlights the diagnostic challenges posed by atypical cystic renal lesions and underscores the importance of integrating imaging, intraoperative findings, and histopathology. Including RECs in the differential diagnosis may prevent unnecessary antituberculous therapy and overtreatment.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076)

## Full-text entities

- **Genes:** CCN6 (cellular communication network factor 6) [NCBI Gene 8838] {aka LIBC, PPAC, PPD, PPRD, WISP-3, WISP3}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** RTAs (MESH:D000141), pseudoaneurysm (MESH:D017541), anxiety (MESH:D001007), bacterial superinfection (MESH:D015163), RECs (MESH:D004814), tuberculous infection (MESH:D007239), muscle (MESH:D019042), tuberculosis (MESH:D014376), flank pain (MESH:D021501), hematuria (MESH:D006417), TB (MESH:D014390), granulomatous inflammation (MESH:D007249), cystic tumor (MESH:D018297), tenderness (MESH:D063806), Tumours of the Urinary (MESH:D014571), pyuria (MESH:D011776), renal tumors (MESH:D007680), malignancy (MESH:D009369), calcification (MESH:D002114), renal tuberculosis (MESH:D014398), cyst (MESH:D003560), infectious (MESH:D003141), HL (MESH:C538324), renal artery pseudoaneurysm (MESH:D012078), mature teratoma (MESH:D013724), urinary tract infections (MESH:D014552), hydronephrosis (MESH:D006869), fever (MESH:D005334), renal mass (MESH:C536030), hereditary kidney disease (MESH:D030342), RTA (MESH:D000038), impaired renal function (MESH:D007674), III (MESH:C537189), dermoid cyst (MESH:D003884), genitourinary malignancies (MESH:D014565), back pain (MESH:D001416), leukocytosis (MESH:D007964), anti (MESH:D006679), bleeding (MESH:D006470), nephrolithiasis (MESH:D053040), cystic lesion (MESH:D052177), weight loss (MESH:D015431), xanthogranulomatous pyelonephritis (MESH:D011705), RCC (MESH:D002292)
- **Chemicals:** ceftriaxone (MESH:D002443), rifampin (MESH:D012293), metronidazole (MESH:D008795), creatinine (MESH:D003404), isoniazid (MESH:D007538), alcohol (MESH:D000438), ethambutol (MESH:D004977), pyrazinamide (MESH:D011718)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mycobacterium tuberculosis (species) [taxon 1773]

## Full text

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## Figures

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## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12321514/full.md

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Source: https://tomesphere.com/paper/PMC12321514