# Granular Cell Tumours of the Breast: A Case Series and Literature Review

**Authors:** Sofeah Samsuddin, Lester Chee Hao Leong, Cheryl Hui Shan Lim, Chow Yin Wong, Ying Ching Tan

PMC · DOI: 10.7759/cureus.87336 · Cureus · 2025-07-05

## TL;DR

This paper presents two cases of benign granular cell tumors in the breast and discusses their similarities to breast malignancies.

## Contribution

The study contributes two new cases of benign granular cell tumors in young women and highlights diagnostic challenges.

## Key findings

- Granular cell tumors in the breast can mimic malignancies in clinical and radiological features.
- The cases presented were benign, but highlight the difficulty in managing such lesions.
- Breast involvement by granular cell tumors is rare and often benign.

## Abstract

Granular cell tumours (GCTs) are rare tumours that can occur in any part of the body but are commonly observed in the skin, digestive tract, and subcutaneous tissues, with the oral cavity being the most common anatomical location. Breast involvement has been reported in a small proportion of cases and is commonly benign. However, some of these lesions can be malignant. In this study, two cases of benign granular breast cell tumours in women aged 31 and 39 years are highlighted and discussed. This study shows similarities between the clinical and radiological presentation of GCTs with breast malignancies and the associated management difficulties that can be encountered.

## Full-text entities

- **Genes:** TP63 (tumor protein p63) [NCBI Gene 8626] {aka AIS, B(p51A), B(p51B), EEC3, KET, LMS}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, KRT14 (keratin 14) [NCBI Gene 3861] {aka CK14, EBS1, EBS1A, EBS1B, EBS1C, EBS1D}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, CD68 (CD68 molecule) [NCBI Gene 968] {aka GP110, LAMP4, SCARD1}, VIM (vimentin) [NCBI Gene 7431]
- **Diseases:** nipple discharge (MESH:C000626393), fibrosis (MESH:D005355), GCTs (MESH:D000230), carcinoma (MESH:D009369), inflammation (MESH:D007249), necrosis (MESH:D009336), benign granular breast cell tumours (MESH:D001943), breast pain (MESH:D059373), malignant breast lesions (MESH:D001941), atypical ductal hyperplasia (MESH:D002285), myoblastoma (MESH:D009379), GCT (MESH:C537296), axillary lymphadenopathy (MESH:D008206), invasive ductal carcinoma (MESH:D044584), calcifications (MESH:D002114)
- **Chemicals:** H&amp;E (MESH:D006371), eosin (MESH:D004801), Hematoxylin (MESH:D006416)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12320961/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12320961/full.md

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Source: https://tomesphere.com/paper/PMC12320961