# Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China

## TL;DR

This study suggests a possible link between SARS-CoV-2 infection during pregnancy and an increased incidence of situs inversus in China.

## Contribution

The study reports a significant rise in situs inversus cases in Henan, China, during the pandemic, despite limited genetic evidence for causation.

## Key findings

- 34 cases of situs inversus were diagnosed in Henan, China, during the pandemic.
- 24 of the 34 cases showed no pathogenic genetic variants.
- A correlation between SARS-CoV-2 infection and situs inversus is suggested.

## Abstract

Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus.