# Undifferentiated Adenocarcinoma With Rhabdoid Features of the Stomach: A Case Report

**Authors:** Soufiane Taibi, Ouryemchi Mouad, Haitam Soussan, Guellil Abdelali, Mohammed Bouziane

PMC · DOI: 10.7759/cureus.87321 · Cureus · 2025-07-05

## TL;DR

A rare case of aggressive stomach cancer with rhabdoid features was diagnosed after multiple tests failed to identify the source of bleeding.

## Contribution

This case report highlights the diagnostic challenges and management of a rare gastric tumor with rhabdoid features.

## Key findings

- The tumor was diagnosed as an undifferentiated adenocarcinoma with rhabdoid features after antrectomy.
- Standard diagnostic methods failed to identify the bleeding source, necessitating surgical intervention.
- The prognosis remains poor despite early diagnosis and treatment.

## Abstract

Rhabdoid tumors are rare and aggressive neoplasms, first described in the kidney, but they have also been reported in various extrarenal sites, including the gastrointestinal tract. Gastric involvement is particularly unusual, often presenting as an adenocarcinoma with rhabdoid features. This type of tumor poses a diagnostic challenge, requiring histological, immunohistochemical, and cytogenetic analyses. Due to the aggressive nature of these tumors, early diagnosis and prompt surgical intervention are essential, although the prognosis remains poor. We report a case of a man with an upper gastrointestinal bleeding where both gastrointestinal endoscopy, colonoscopy, and even the abdominal scan failed to identify the origin of bleeding; considering these results, a Weinberg procedure was performed. In light of the continued deterioration, antrectomy was deemed necessary, after which anatomopathological findings were consistent with an undifferentiated adenocarcinoma of the stomach exhibiting rhabdoid features.

## Full-text entities

- **Genes:** VIM (vimentin) [NCBI Gene 7431], MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1) [NCBI Gene 6598] {aka BAF47, CSS3, INI-1, INI1, MRD15, PPP1R144}
- **Diseases:** hematemesis (MESH:D006396), bleeding (MESH:D006470), Gastric cancer (MESH:D013274), Rhabdoid (MESH:D018335), gastrointestinal neoplasms (MESH:D005770), alcoholism (MESH:D000437), weight loss (MESH:D015431), hypochromic anemia (MESH:D000747), metastases (MESH:D009362), necrosis (MESH:D009336), chromosomal abnormalities (MESH:D002869), monosomy 22 (MESH:C536798), Gastric involvement (MESH:D013272), lymphoma (MESH:D008223), pleomorphic giant cell carcinoma (MESH:D018286), splenomegaly (MESH:D013163), adenopathy (MESH:D000072281), Undifferentiated Adenocarcinoma (MESH:D000230), Tumor (MESH:D009369), gastrointestinal bleeding (MESH:D006471)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12320193/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12320193/full.md

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Source: https://tomesphere.com/paper/PMC12320193