# Primary malignant melanoma of the female urethra: A rare case report

**Authors:** Anahita Ansari Djafari, Mohammad Seifi Poor, Sina Samenezhad, Reza Nicknama, Azadeh Rakhshan

PMC · DOI: 10.1016/j.eucr.2025.103133 · Urology Case Reports · 2025-07-22

## TL;DR

A rare case of malignant melanoma in a woman's urethra highlights the need for early diagnosis and treatment to improve outcomes.

## Contribution

This case report adds to the limited literature on primary urethral melanoma and emphasizes diagnostic challenges.

## Key findings

- A 61-year-old woman was diagnosed with primary malignant melanoma of the urethra after initial misdiagnosis.
- Despite complete surgical resection, the cancer metastasized within six months.
- The case highlights the importance of considering melanoma in the differential diagnosis of urethral masses.

## Abstract

A 61y/o woman who presented with a dark, bleeding mass at the urethral meatus, accompanied by dysuria and significant weight loss. Initial diagnosis by a GP suggested a urethral caruncle. Imaging revealed a urethral mass, which was surgically excised. Histopathological examination confirmed the diagnosis of malignant melanoma. Despite complete surgical resection, follow-up imaging 6 months later revealed widespread metastases. She was referred for systemic and immunotherapy. This case underscores the importance of considering urethral melanoma in the differential diagnosis of urethral masses, especially when the presentation mimics benign conditions. Early recognition, thorough staging and prompt intervention are crucial for improving outcomes.

## Linked entities

- **Diseases:** malignant melanoma (MONDO:0005105)

## Full-text entities

- **Genes:** MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}
- **Diseases:** Malignant melanoma (MESH:D008545), urethral caruncle (MESH:D014526), weight loss (MESH:D015431), polyps (MESH:D011127), transitional cell carcinoma (MESH:D002295), metastases (MESH:D009362), fistula (MESH:D005402), pigmentation (MESH:D010859), cutaneous lesions (MESH:D009059), cervical adenocarcinoma (MESH:D000230), malignancy (MESH:D009369), incontinence (MESH:D014549), hematuria (MESH:D006417), mucosal prolapse (MESH:D011391), organomegaly (MESH:D016878), bleeding (MESH:D006470), Urethral mass (MESH:D014522), sarcoma of the urethra (MESH:D014523), dysuria (MESH:D053159)
- **Chemicals:** H&amp;E (MESH:D006371), melanin (MESH:D008543), 18F-FDG (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12320086/full.md

## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12320086/full.md

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Source: https://tomesphere.com/paper/PMC12320086