# Spontaneous intramural hematoma of the small bowel in anticoagulated patients—Insights into management: A case report

**Authors:** Ali Hajihashemi, Hadi Khanifar, Mahsa Geravandi

PMC · DOI: 10.1016/j.radcr.2025.06.079 · Radiology Case Reports · 2025-07-28

## TL;DR

This case report discusses two instances of rare small bowel intramural hematoma in patients on anticoagulants and highlights effective conservative and surgical management strategies.

## Contribution

The report provides clinical insights into managing spontaneous small bowel hematoma in anticoagulated patients through conservative and surgical approaches.

## Key findings

- Conservative treatment with vitamin K and plasma transfusion led to full recovery in both patients.
- Transitioning from warfarin to direct oral anticoagulants prevented recurrence in both cases.
- Prompt diagnosis and multidisciplinary management improved outcomes in these patients.

## Abstract

Intramural hematoma of the small bowel is a rare but potentially life-threatening complication of anticoagulation therapy, most commonly associated with warfarin use. This report presents two cases highlighting the clinical presentation and management of this condition. The first case involved a 72-year-old male with a history of heart valve replacement who presented with severe abdominal pain, nausea, and vomiting; imaging revealed a jejunal intramural hematoma and a significantly elevated INR. The second case involved a 51-year-old female with atrial fibrillation who experienced acute abdominal pain and partial bowel obstruction; CT imaging showed an intramural hematoma in the ileum with associated hemoperitoneum. Both patients were treated conservatively through cessation of warfarin, administration of vitamin K, and transfusion of fresh-frozen plasma, with one requiring surgical exploration but no bowel resection. Full recovery was achieved in both cases, and patients were safely transitioned to direct oral anticoagulants with no recurrence. These cases underscore the need for prompt diagnosis and multidisciplinary management in anticoagulated patients presenting with abdominal symptoms to prevent serious complications and improve outcomes.

## Linked entities

- **Chemicals:** warfarin (PubChem CID 54678486), vitamin K (PubChem CID 5280483)
- **Diseases:** atrial fibrillation (MONDO:0004981)

## Full-text entities

- **Diseases:** metastasis (MESH:D009362), gastroenteritis (MESH:D005759), bowel obstruction (MESH:D012778), gastrointestinal complications (MESH:D005767), hypertension (MESH:D006973), leukemia (MESH:D007938), idiopathic thrombocytopenic purpura (MESH:D016553), atrial fibrillation (MESH:D001281), tenderness (MESH:D063806), ischemic (MESH:D002545), inflammatory bowel disease (MESH:D015212), overweight (MESH:D050177), abdominal trauma (MESH:D000007), pancreatic carcinoma (MESH:D010190), hematoma (MESH:D006406), osteoarthritis (MESH:D010003), vasculitis (MESH:D014657), Abdominal pain (MESH:D015746), irritable bowel syndrome (MESH:D043183), urologic disorders (MESH:D014570), myeloma (MESH:D009101), hemophilia (MESH:D006467), pain (MESH:D010146), hemoperitoneum (MESH:D006465), type 2 diabetes mellitus (MESH:D003924), vascular fragility (MESH:D005600), rectal bleeding (MESH:D012002), toxicity (MESH:D064420), pneumoperitoneum (MESH:D011027), gastrointestinal bleeding (MESH:D006471), CKD (MESH:D051436), bowel ischemia (MESH:D007511), infection (MESH:D007239), inflammation (MESH:D007249), trauma (MESH:D014947), malignancies (MESH:D009369), function (MESH:D003291), nausea (MESH:D009325), vomiting (MESH:D014839), IMH (MESH:D000094666), bleeding (MESH:D006470), peripheral edema (MESH:D004487), bruising (MESH:D003288), jaundice (MESH:D007565), constipation (MESH:D003248), organomegaly (MESH:D016878), nephropathy (MESH:D007674), lymphoma (MESH:D008223), intestinal obstruction (MESH:D007415), perforation (MESH:D057112), acute appendicitis (MESH:D001064), pancreatitis (MESH:D010195)
- **Chemicals:** rivaroxaban (MESH:D000069552), Warfarin (MESH:D014859), heparin (MESH:D006493), vitamin K (MESH:D014812), amlodipine (MESH:D017311), DOACs (-), metformin (MESH:D008687), coumarin (MESH:C030123)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12320024/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12320024/full.md

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Source: https://tomesphere.com/paper/PMC12320024