# The short term impact of uncomplicated cataract surgery on retinal layers thickness

**Authors:** Marco Gioia, Maddalena De Bernardo, Aniello La Marca, Martina De Luca, Sergio Pagliarulo, Mariagrazia Avella, Alfredo Mignone, Nicola Rosa

PMC · DOI: 10.3389/fmed.2025.1537402 · Frontiers in Medicine · 2025-07-21

## TL;DR

This study examines how cataract surgery affects retinal layer thickness in the short term.

## Contribution

It identifies specific retinal layers that show significant thickness changes after cataract surgery.

## Key findings

- Inner retinal layers and the entire retina showed significant thickening in foveal and parafoveal regions.
- Outer retinal layers showed significant thinning in parafoveal regions after surgery.

## Abstract

To detect the short-term impact of cataract surgery on retinal layers thickness, as the exact mechanism of fundus changes after phacoemulsification has not yet been fully clarified.

A retrospective observational study.

Seventy eyes of 70 patients with age ranging from 49 to 92 years, scheduled for cataract surgery, were included.

All subjects underwent a complete ophthalmological examination, including ART-OCT volume with Heidelberg Spectralis before and approximately one month later cataract surgery.

The macula was divided into a central foveal region and four parafoveal regions (superior, inferior, nasal, temporal). The scans were then automatically segmented into the different retinal layers and the changes in each layer were assessed.

The results revealed that both the inner retinal layers and the entire retina exhibited a statistically significant thickening in foveal and parafoveal region: IRL (p < 0.001), ONL (p < 0.001), GCL (p = 0.010), RNFL (p = 0.020), and ALL (p < 0.001). Conversely, the outer retinal layers showed a statistically significant reduction in thickness only within the parafoveal regions: ORL (p < 0.001).

This study may provide a pathophysiological explanation for post-phacoemulsification changes affecting the retina.

## Linked entities

- **Diseases:** cataract (MONDO:0005129)

## Full-text entities

- **Genes:** PRL (prolactin) [NCBI Gene 5617] {aka GHA1, pPRL}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}
- **Diseases:** decline in visual function (MESH:D014786), segment (MESH:C537538), hypertensive retinopathy (MESH:D058437), macular hole (MESH:D012167), diabetic retinopathy (MESH:D003930), AMD (MESH:D006009), autoimmune diseases (MESH:D001327), corneal leukoma (MESH:D003318), ocular hypotony (MESH:D015814), hypertension (MESH:D006973), optic neuropathy (MESH:D009901), uveitis (MESH:D014605), Irvine Gass syndrome (MESH:D008269), retinal (MESH:D012173), central serous chorioretinopathy (MESH:D056833), mydriasis (MESH:D015878), inflammation (MESH:D007249), age-related macular degeneration (MESH:D008268), epiretinal membrane (MESH:D019773), nuclear or (MESH:C564596), Cataract (MESH:D002386), diseases (MESH:D004194), glaucoma (MESH:D005901)
- **Chemicals:** oxygen (MESH:D010100), ropivacaine (MESH:D000077212), cefuroxime (MESH:D002444), PCB00 (-), diclofenac (MESH:D004008), povidone iodine (MESH:D011206), prostaglandins (MESH:D011453), phenylephrine hydrochloride (MESH:D010656), levofloxacin (MESH:D064704), CHO (MESH:C034482), tropicamide (MESH:D014331), dexamethasone (MESH:D003907)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12319017/full.md

## References

41 references — full list in the complete paper: https://tomesphere.com/paper/PMC12319017/full.md

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Source: https://tomesphere.com/paper/PMC12319017