# Suicide risk remission in collaborative care: a large-scale observational study

**Authors:** Carol Hardy, Virna Little, Brandn Green

PMC · DOI: 10.3389/fpsyt.2025.1584753 · Frontiers in Psychiatry · 2025-07-21

## TL;DR

A large study finds that longer treatment and more frequent care in primary settings can reduce suicide risk, especially for those with less severe depression.

## Contribution

The study identifies how treatment duration and contact frequency impact suicide risk remission in primary care, moderated by depression severity.

## Key findings

- Longer enrollment and more clinical touchpoints predicted improved suicide risk outcomes.
- Higher baseline depression scores predicted poorer outcomes but were moderated by treatment duration.
- More psychiatric consultations were linked to risk regression, possibly due to case complexity.

## Abstract

Primary care settings represent a critical opportunity for suicide prevention, as many individuals who die by suicide visit primary care providers in their final month of life. The Collaborative Care Model (CoCM) offers a structured approach to behavioral health treatment in primary care, but research on its effectiveness for suicide risk management is limited. This study examined how clinical variables (days enrolled, clinical touchpoints, psychiatric consultations) relate to suicide risk outcomes in CoCM, and how these relationships are moderated by initial depression severity.

Data from 3,599 patients with suicide risk flags who completed CoCM treatment were analyzed using ordinal logistic regression. Changes in suicide risk level from intake to discharge were categorized as improved, unchanged, or regressed.

Longer enrollment (OR=1.432, p<.001) and more clinical touchpoints (OR=2.584, p<.001) predicted improved outcomes. Higher baseline depression scores predicted poorer outcomes (OR=0.741, p<.001) but showed significant interaction with days enrolled. More psychiatric consultations (OR=0.813, p<.001) were associated with risk regression, likely reflecting appropriate escalation of complex cases.

CoCM shows promise for suicide risk management in primary care, with sustained engagement and frequent clinical contact improving outcomes. Results suggest treatment intensity should be tailored to initial depression severity.

## Linked entities

- **Diseases:** depression (MONDO:0002050)

## Full-text entities

- **Genes:** MLC1 (modulator of VRAC current 1) [NCBI Gene 23209] {aka LVM, MLC, VL}
- **Diseases:** anxiety disorders (MESH:D001008), Psychiatric (MESH:D001523), diabetes (MESH:D003920), suicidal ideation (MESH:D001072), CoCM (MESH:D004195), death (MESH:D003643), cardiovascular disease (MESH:D002318), anxiety (MESH:D001007), Depression (MESH:D003866), behavioral health condition (MESH:D000071069), psychotic (MESH:D011618)
- **Chemicals:** CoCM (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12319016/full.md

## References

51 references — full list in the complete paper: https://tomesphere.com/paper/PMC12319016/full.md

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Source: https://tomesphere.com/paper/PMC12319016