# Case Report: Carotid cavernous fistula presenting as red eye: case illustration and comprehensive review

**Authors:** Qi-Bin Xu, Wen-Yan Sheng

PMC · DOI: 10.3389/fmed.2025.1613326 · Frontiers in Medicine · 2025-07-21

## TL;DR

This case report highlights a rare condition causing red eye, emphasizing the importance of accurate diagnosis to avoid delays in treatment.

## Contribution

The report provides a detailed case illustration and comprehensive review of carotid cavernous fistula presenting as red eye.

## Key findings

- CCF can present with red eye and proptosis, often misdiagnosed as conjunctivitis.
- Pre- and postoperative photographs help in understanding ophthalmic features of CCF.
- Early diagnosis and treatment are crucial for effective management of CCF.

## Abstract

Carotid cavernous fistula (CCF) is a pathological condition where an abnormal connection forms between the carotid artery and the cavernous sinus. This condition can lead to a variety of ocular and neurological symptoms, often making it difficult to diagnose, especially when patients present with common ocular complaints such as red eye, which is often misdiagnosed as conjunctivitis. The subtle and diverse symptoms of CCF can lead to misdiagnosis, delaying appropriate treatment. This article reports a case of CCF that initially presented with red eye and proptosis, leading to an ophthalmology referral. By comparing pre- and postoperative ocular photographs, the article provides a detailed review of the ophthalmic features, classification, diagnostic methods, and treatment options for CCF. The aim is to enhance clinicians’ understanding of this condition, improve diagnostic accuracy at initial presentation, and promote timely and effective treatment.

## Linked entities

- **Diseases:** conjunctivitis (MONDO:0003799)

## Full-text entities

- **Diseases:** thyroid eye disease (MESH:D049970), carotid compression (MESH:D009408), neurological complications (MESH:D002493), ocular motility impairments (MESH:D015835), ocular diseases (MESH:D005128), conjunctivitis (MESH:D003231), fistula (MESH:D005402), congestion (MESH:D002311), edema (MESH:D004487), optic neuropathy (MESH:D009901), systemic diseases (MESH:D034721), left eye proptosis (MESH:D005094), glaucoma (MESH:D005901), orbital inflammatory syndrome (MESH:D016727), ocular abnormalities (MESH:D005124), conjunctival chemosis (MESH:D003229), cranial nerve palsy and related disorders (MESH:D003389), CCF (MESH:D020216), trauma (MESH:D014947), visual disturbances (MESH:D014786), thrombosis (MESH:D013927), elevated intraocular pressure (MESH:D019586)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12318932/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12318932/full.md

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Source: https://tomesphere.com/paper/PMC12318932