# Acute Liver Failure Secondary to Primary Large B-cell Lymphoma Complicated by Malignancy-related Hemophagocytic Syndrome: A Case Report

## TL;DR

A 36-year-old patient with acute liver failure was diagnosed with a rare lymphoma and hemophagocytic syndrome, and successfully treated with chemotherapy.

## Contribution

This case report highlights the rare association of primary large B-cell lymphoma with hemophagocytic syndrome and acute liver failure.

## Key findings

- A liver biopsy confirmed primary large B-cell lymphoma as the cause of acute liver failure.
- Bone marrow biopsy confirmed the presence of malignancy-related hemophagocytic syndrome.
- R-CHOEP chemotherapy led to successful recovery and hospital discharge.

## Abstract

Acute liver failure is a catastrophic condition characterized by the sudden and severe impairment of hepatic function. We report the case of a 36-year-old patient who presented with significant dehydration, generalized jaundice, evidence of hepatic encephalopathy, generalized edema with abdominal distension, and hepatosplenomegaly. A liver biopsy was performed, yielding the final diagnosis of primary large B-cell lymphoma. Subsequently, a bone marrow aspirate and biopsy were performed, confirming the diagnosis of hemophagocytic syndrome. The patient was managed with R-CHOEP (rituximab, cyclophosphamide, doxorubicin, vincristine, etoposide, prednisone) chemotherapy. After 21 days, the patient was successfully discharged to continue treatment on an outpatient basis.