# Antineutrophil Cytoplasmic Antibody-Negative Pauci-Immune Crescentic Glomerulonephritis in Systemic Lupus Erythematosus: A Case Report and Literature Review

## TL;DR

A rare case of ANCA-negative pauci-immune crescentic glomerulonephritis in a systemic lupus erythematosus patient is reported and reviewed.

## Contribution

A novel case of ANCA-negative PICG in SLE is documented and discussed in the context of existing literature.

## Key findings

- An SLE patient developed ANCA-negative PICG requiring renal replacement therapy.
- The patient responded well to treatment despite severe kidney injury.
- Literature review highlights the rarity of PICG in the context of lupus nephritis.

## Abstract

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and often presents as an immune complex-mediated glomerular disease. While pauci-immune crescentic glomerulonephritis (PICG) is commonly associated with antineutrophil cytoplasmic antibodies (ANCAs), its occurrence in the context of LN is rare. We report a case of an SLE patient who developed acute kidney injury due to ANCA-negative PICG. The kidney injury was severe enough to necessitate renal replacement therapy; however, the patient responded well to treatment. We also review the literature and previously reported cases of PICG in patients with SLE.