# Presumed Posterior Scleritis Complicated by Serous Retinal Detachment as a Possible Late Manifestation of COVID-19 Infection: A Pediatric Case Report

**Authors:** Jared J Tuttle, Shannon D Scarboro, Clio A Harper III, Taylor Lind, Ryan C Young

PMC · DOI: 10.7759/cureus.87284 · Cureus · 2025-07-04

## TL;DR

An 11-year-old girl developed eye inflammation and retinal detachment a year after recovering from COVID-19, suggesting a possible long-term ocular effect of the virus.

## Contribution

This is the first reported case of posterior scleritis with serous retinal detachment as a late manifestation of COVID-19 in a pediatric patient.

## Key findings

- The patient showed clinical signs of posterior scleritis and serous retinal detachment one year after confirmed COVID-19 infection.
- Treatment with corticosteroids and anti-inflammatory drugs resolved symptoms and restored vision.
- The case suggests a possible link between delayed ocular inflammation and prior COVID-19 infection.

## Abstract

A wide range of systemic and ocular symptoms have been associated with 2019 novel coronavirus (COVID-19) infection, including long-term alterations in inflammatory pathways. We describe a novel case of an 11-year-old female presenting with posterior scleritis and associated serous retinal detachment, occurring one year after confirmed COVID-19 infection. The patient presented with a one-day history of central scotoma following three days of progressive right eye pain, photophobia, conjunctival injection, and blurred vision. She reported two prior episodes of right eye pain, the first of which occurred in the setting of acute COVID-19 infection. Examination revealed clinical signs of posterior scleritis with serous retinal detachment. Laboratory work-up for infectious and autoimmune etiologies was unremarkable. The patient was treated with topical corticosteroids and nonsteroidal anti-inflammatory therapy, resulting in complete resolution of symptoms and restoration of visual acuity. Despite the atypical response, posterior scleritis remains the presumed diagnosis based on recurrent episodes and clinical findings. The temporal association with initial COVID-19 infection raises the possibility of an etiological role, though it remains unclear whether persistent viral antigens or a dysregulated immune response underlie the condition. This case introduces posterior scleritis as a potential delayed ocular manifestation of COVID-19 infection and highlights the need for further research into post-viral inflammatory responses affecting the eye. For clinicians, it emphasizes the importance of considering recent or remote COVID-19 infection in the differential diagnosis of posterior segment inflammation.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096), posterior scleritis (MONDO:0001774)

## Full-text entities

- **Genes:** HLA-A (major histocompatibility complex, class I, A) [NCBI Gene 3105] {aka HLAA}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** tuberculosis (MESH:D014376), TB (MESH:D014390), post- (MESH:D000094025), optic neuritis (MESH:D009902), eye pain (MESH:D058447), Posterior Scleritis (MESH:D015423), VKH (MESH:D014607), Guillain-Barre syndrome (MESH:D020275), multisystem inflammatory syndrome (MESH:C000705967), blurred vision (MESH:D014786), optic nerve edema (MESH:D000080344), Serous Retinal Detachment (MESH:D012163), antinuclear antibody (MESH:D007153), 2019 novel coronavirus (MESH:D000086382), autoimmune diseases (MESH:D001327), attention-deficit/hyperactivity disorder (MESH:D001289), photophobia (MESH:D020795), inflammation (MESH:D007249), eye movement (MESH:D015835), infection (MESH:D007239), retinitis (MESH:D012173), choroidal detachment (MESH:D000080324), central serous chorioretinopathy (MESH:D056833), posterior (MESH:D001041), Conjunctivitis (MESH:D003231), uveitis (MESH:D014605), long COVID (MESH:D000094024), fever (MESH:D005334), joint pain or swelling (MESH:D018771), fluid (MESH:D002559), periorbital edema (MESH:D004487), congenital optic disc (MESH:D009901), scleral thickening (MESH:D015422), ANCA (MESH:D056648), neuropathic pain (MESH:D009437), serous (MESH:D018297), conjunctival redness (MESH:D003229), autoinflammatory (MESH:D056660), rash (MESH:D005076), cough (MESH:D003371), viral infection (MESH:D014777), hypercoagulability (MESH:D019851), scotoma (MESH:D012607), rheumatologic disorder (MESH:D012216), ocular surface abnormalities (MESH:D010534), retinal vein occlusion (MESH:D012170), dull pain (MESH:D010146), MIS-C (MESH:C000718087), drug allergies (MESH:D004342)
- **Chemicals:** ICGA (-), tobramycin (MESH:D014031), amphetamine (MESH:D000661), ibuprofen (MESH:D007052), Pen (MESH:C058388), FA (MESH:D005492), indocyanine green (MESH:D007208), prednisolone (MESH:D011239), dextroamphetamine (MESH:D003913), ketorolac (MESH:D020910), Fluorescein (MESH:D019793), dexamethasone (MESH:D003907), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12318532/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12318532/full.md

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Source: https://tomesphere.com/paper/PMC12318532