# Effect of Contrast Media Type on Renal Function in Percutaneous Coronary Intervention (PCI): A Propensity Score-Matched Analysis Considering Contrast Media Volume and Preoperative Renal Function

## TL;DR

This study found no significant difference in kidney function after heart procedures using two types of contrast dyes.

## Contribution

A propensity score-matched analysis comparing renal effects of iohexol and iomeprol in PCI patients.

## Key findings

- No significant differences in eGFR changes between iohexol and iomeprol groups at 24 hours post-PCI.
- No significant differences in eGFR changes between the two contrast media groups at more than 72 hours post-PCI.
- No cases of post-contrast acute kidney injury were observed in either group.

## Abstract

Objective

To compare the effects of two low-osmolar contrast media (LOCM), iohexol and iomeprol, on renal function in patients undergoing percutaneous coronary intervention (PCI), as measured by estimated glomerular filtration rate (eGFR).

Methods

This retrospective study included 180 patients who underwent PCI between January 2021 and December 2022. After propensity score matching based on age, sex, diabetes mellitus, pre-PCI eGFR, contrast media volume, and left ventricular ejection fraction, 88 patients who received either iohexol or iomeprol (44 each) were analyzed. Changes in eGFR at 24 hours and more than 72 hours post-PCI were evaluated.

Results

There were no differences between the two groups in age [median 71.5 (range 33-86) vs. 73 (range 50-83) years], gender [35 (79.5%) vs. 37 (84.1%) male], pre-PCI eGFR [64.9 (6.8-112.2) vs. 61.3 (8.5-105.2) ml/min/1.73m²], or amount of LOCM used [108 (42-217) vs. 109 (52-222) ml] between the iohexol and iomeprol groups, respectively. No significant differences in absolute or relative changes in eGFR were observed between the two groups at either time point. At 24 hours, the mean relative change in eGFR was 1.6% (-2.5 to 5.8) in the iohexol group and 1.1% (-2.8 to 4.9) in the iomeprol group. At more than 72 hours, relative changes were -2.1% (-5.9 to 1.7) and -0.3% (-4.4 to 3.8), respectively. No cases of post-contrast acute kidney injury were observed.

Conclusion

Changes in renal function after PCI did not differ significantly between iohexol and iomeprol, despite differences in osmolality and viscosity.