# Unmasking Myopericarditis Behind an ST-Segment Elevation Myocardial Infarction (STEMI) Presentation

**Authors:** Lazaro Basart, Oscar Diaz, Jasmandeep Bhandal, Montadar Mohana, Kevin Sande, Mariano Razzeto

PMC · DOI: 10.7759/cureus.87226 · Cureus · 2025-07-03

## TL;DR

A case study shows how myopericarditis can mimic a heart attack, emphasizing the need for careful diagnosis to avoid unnecessary procedures.

## Contribution

This paper presents a clinical case highlighting the diagnostic challenge of myopericarditis mimicking STEMI.

## Key findings

- A patient with STEMI-like symptoms had no obstructive coronary disease, leading to a myopericarditis diagnosis.
- Clinical presentation and tests revealed diastolic dysfunction and a trivial pericardial effusion.
- The case underscores the importance of a broad differential diagnosis in acute coronary syndrome presentations.

## Abstract

Myopericarditis is an inflammatory cardiac condition that can closely mimic ST-elevation myocardial infarction (STEMI), presenting with chest pain, elevated troponin levels, and ST-segment changes on electrocardiogram (ECG). We present the case of a 46-year-old man with a history of hypertension who presented to the emergency department with sudden-onset, substernal chest pain that awoke him from sleep. The pain was described as crushing in nature, associated with diaphoresis, and was initially attributed to anxiety. Electrocardiography revealed ST-segment elevations in leads II, III, and aVF, with reciprocal changes and an incomplete right bundle branch block (IRBBB). Initial troponin I was markedly elevated at 16.9 ng/mL. Given these concerning findings, the patient underwent emergent cardiac catheterization. Coronary angiography revealed no obstructive coronary artery disease, and left ventriculography demonstrated preserved systolic function. Further evaluation uncovered a recent viral upper respiratory infection, and transthoracic echocardiography showed diastolic dysfunction with a trivial pericardial effusion. The combination of clinical presentation, elevated cardiac markers, ST-segment changes, and absence of coronary pathology led to the diagnosis of myopericarditis. This case highlights the importance of maintaining a broad differential diagnosis in patients presenting with apparent acute coronary syndromes and underscores the need for comprehensive assessment to avoid unnecessary interventions.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** myocarditis (MESH:D009205), effusions (MESH:D000080324), inflammation (MESH:D007249), elevation (MESH:D006937), left ventricular hypertrophy (MESH:D017379), inflammatory cardiac condition (MESH:D006331), coronary disease (MESH:D003327), arrhythmias (MESH:D001145), ACS (MESH:D054058), depressions (MESH:D003866), necrosis (MESH:D009336), tachycardia (MESH:D013610), cough (MESH:D003371), myocardial involvement (MESH:C564676), pericardial effusion (MESH:D010490), anxiety (MESH:D001007), NOD (MESH:D001157), Viral myocarditis (MESH:D014777), IRBBB (MESH:D002037), pulmonary embolism (MESH:D011655), respiratory infection (MESH:D012141), Chest pain (MESH:D002637), Myopericarditis (MESH:D010146), ischemia (MESH:D007511), Acute pericarditis (MESH:D010493), acute MI (MESH:D000208), influenza (MESH:D007251), cardiomyopathy (MESH:D009202), ischemic (MESH:D002545), coronary artery obstruction (MESH:D000088442), hypertension (MESH:D006973), sinus tachycardia (MESH:D013616), coronary artery disease (MESH:D003324), sore throat (MESH:D010612), myocardial infarction (MESH:D009203), COVID-19 (MESH:D000086382), ST-Segment Elevation Myocardial Infarction (MESH:D000072657), cardiac syndromes (MESH:D017566), deep vein thrombosis (MESH:D020246), diastolic dysfunction (MESH:D018487)
- **Chemicals:** gadolinium (MESH:D005682), colchicine (MESH:D003078)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12318142/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12318142/full.md

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Source: https://tomesphere.com/paper/PMC12318142