# Acute Scrotal Pain and Swelling as an Atypical Presentation of Sweet’s Syndrome

**Authors:** Jeffrey Jiang, An Huynh, Angel Wu, Alexander Nirenberg, Weranja Ranasinghe

PMC · DOI: 10.7759/cureus.87218 · Cureus · 2025-07-03

## TL;DR

A healthy man presented with scrotal pain and swelling, which was later diagnosed as Sweet’s Syndrome, an atypical case requiring careful diagnosis.

## Contribution

This case report presents an atypical clinical manifestation of Sweet’s Syndrome without typical risk factors.

## Key findings

- The patient had no rheumatological or malignant risk factors, making the diagnosis challenging.
- Steroid treatment and skin biopsy were essential in confirming Sweet’s Syndrome.

## Abstract

We present a unique case of Sweet’s syndrome associated with scrotal pain and swelling in a healthy male with no rheumatological or malignant risk factors. In the absence of typical urological presentations, diagnostic challenges included ruling out surgical emergencies in addition to skin biopsy and commencement of steroid treatment. This case highlights the importance of comprehensive examination and investigation to prevent surgical complications and consideration of rheumatological pathologies in atypical scrotal presentations.

## Full-text entities

- **Diseases:** Sweet's Syndrome (MESH:D016463), Swelling (MESH:D004487), Scrotal Pain (MESH:D010146), rheumatological (MESH:D012216)
- **Chemicals:** steroid (MESH:D013256)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12317370/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12317370/full.md

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Source: https://tomesphere.com/paper/PMC12317370