# Tracheomalacia and Interstitial Pneumonia in a 95-Year-Old Woman With Undiagnosed Rheumatoid Arthritis: A Case Report

**Authors:** Natsumi Yamamoto, Shiho Amano, Kohei Oka, Chiaki Sano, Ryuichi Ohta

PMC · DOI: 10.7759/cureus.87205 · Cureus · 2025-07-02

## TL;DR

An elderly woman with undiagnosed rheumatoid arthritis developed severe respiratory issues, which improved with immunosuppressive treatment.

## Contribution

Highlights the importance of considering late-onset autoimmune diseases in elderly patients with unexplained respiratory symptoms.

## Key findings

- Tracheomalacia and interstitial pneumonia were diagnosed in a 95-year-old with undiagnosed rheumatoid arthritis.
- Immunosuppressive therapy improved the patient's condition.
- Systemic evaluation is crucial for elderly patients with unexplained respiratory symptoms.

## Abstract

This case report describes a 95-year-old woman with a history of cardiovascular and gastrointestinal diseases who presented with fever and anorexia. She was diagnosed with influenza A and secondary bacterial pneumonia. Despite antiviral and antibiotic treatment, her respiratory condition worsened. Detailed examination revealed characteristic joint deformities, elevated rheumatoid factor, and anti-cyclic citrullinated peptide antibodies. Imaging showed interstitial pneumonia and paradoxical breathing with elevation of the membranous portion of the trachea, indicating tracheomalacia. The patient was diagnosed with previously unrecognized rheumatoid arthritis with associated interstitial pneumonia and tracheomalacia. Immunosuppressive therapy with prednisolone and azathioprine improved her condition. This case highlights the importance of thorough systemic evaluation in elderly patients with unexplained respiratory symptoms and the need to consider late-onset autoimmune diseases, including rheumatoid arthritis, in the differential diagnosis.

## Linked entities

- **Chemicals:** prednisolone (PubChem CID 5755), azathioprine (PubChem CID 2265)
- **Diseases:** rheumatoid arthritis (MONDO:0008383)

## Full-text entities

- **Diseases:** influenza A (MESH:D007251), anorexia (MESH:D000855), cardiovascular and gastrointestinal diseases (MESH:D005767), autoimmune diseases (MESH:D001327), Tracheomalacia (MESH:D055090), Rheumatoid Arthritis (MESH:D001172), fever (MESH:D005334), Interstitial Pneumonia (MESH:D017563), bacterial pneumonia (MESH:D018410), joint deformities (MESH:D016916)
- **Chemicals:** azathioprine (MESH:D001379), prednisolone (MESH:D011239), cyclic citrullinated peptide (MESH:C487763)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12317295/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12317295/full.md

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Source: https://tomesphere.com/paper/PMC12317295