# Heterozygous Mutations of PTEN in Macrocephaly Patient With Epilepsy: A Case Report

## TL;DR

A 34-year-old man with macrocephaly and epilepsy was found to have a PTEN gene mutation, linking it to neurological conditions.

## Contribution

The study identifies a specific PTEN mutation associated with macrocephaly and epilepsy, expanding its known clinical implications.

## Key findings

- A heterozygous PTEN mutation (c.4375C > T) was found in a patient with macrocephaly and epilepsy.
- The PTEN mutation may increase the risk of developing macrocephaly with epilepsy.

## Abstract

Phosphatase and tensin homolog (PTEN), a tumor suppressor gene, is also associated with neurological phenotypes, including macrocephaly, Cowden syndrome, and autism spectrum disorder. We present a 34-year-old Chinese male who complained of recurrent seizures within one year. His occipital frontal circumference was 62.8 cm. Whole-exon sequencing revealed that he carried a heterozygous missense mutation of NM_000314.4:c.4375C > T (p.Met35Val) in PTEN gene. Therefore, heterozygous mutations of c.103A > G in PTEN may increase the risk of macrocephaly with epilepsy.