# Common signatures of neutrophils in diverse disease conditions **Authors:** Di Wu, Ying Cao, Hongjie Chen, Minghao Du, Tingting Wang, Jiarui Zhao, Mengyuan Li, Wenjing Wu, Huixuan Zhang, Ence Yang, Jing Yang, Jian Chen PMC · DOI: 10.1038/s41421-025-00818-9 · Cell Discovery · 2025-08-01 ## Full-text entities - **Genes:** Cd244a (CD244 molecule A) [NCBI Gene 18106] {aka 2B4, C9.1, Cd244, F730046O15Rik, Ly90, NAIL}, Tgfb1 (transforming growth factor, beta 1) [NCBI Gene 21803] {aka TGF-beta1, TGFbeta1, Tgfb, Tgfb-1}, Ifng (interferon gamma) [NCBI Gene 15978] {aka IFN-g, If2f, Ifg}, Cxcr2 (C-X-C motif chemokine receptor 2) [NCBI Gene 12765] {aka CD128, CDw128, Cmkar2, Gpcr16, IL-8Rh, IL-8rb}, Mki67 (antigen identified by monoclonal antibody Ki 67) [NCBI Gene 17345] {aka D630048A14Rik, Ki-67, Ki67}, Il4ra (interleukin 4 receptor, alpha) [NCBI Gene 16190] {aka CD124, Il4r}, Rag2 (recombination activating gene 2) [NCBI Gene 19374] {aka Rag-2}, H2-Eb1 (histocompatibility 2, class II antigen E beta) [NCBI Gene 14969] {aka Eb, H-2Eb, H2Eb, Ia-4, Ia4}, CD244 (CD244 molecule) [NCBI Gene 51744] {aka 2B4, NAIL, NKR2B4, Nmrk, SLAMF4}, Camp (cathelicidin antimicrobial peptide) [NCBI Gene 12796] {aka CAP18, CLP, Cnlp, Cramp, FALL39, MCLP}, Tnf (tumor necrosis factor) [NCBI Gene 21926] {aka DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa}, Ifna (interferon alpha complex region) [NCBI Gene 111654] {aka Ifa, Ifa8}, Ccl3 (C-C motif chemokine ligand 3) [NCBI Gene 20302] {aka G0S19-1, LD78alpha, MIP-1alpha, MIP1-(a), MIP1-alpha, Mip1a}, Cd274 (CD274 antigen) [NCBI Gene 60533] {aka A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1}, CCL4 (C-C motif chemokine ligand 4) [NCBI Gene 6351] {aka ACT2, AT744.1, G-26, HC21, LAG-1, LAG1}, Il6 (interleukin 6) [NCBI Gene 16193] {aka Il-6}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, HAVCR2 (hepatitis A virus cellular receptor 2) [NCBI Gene 84868] {aka CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, Erbb2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 13866] {aka Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, LAG3 (lymphocyte activating 3) [NCBI Gene 3902] {aka CD223}, IL4R (interleukin 4 receptor) [NCBI Gene 3566] {aka CD124, IL-4RA, IL4RA}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}, Cd34 (CD34 antigen) [NCBI Gene 12490], Ifnb1 (interferon beta 1, fibroblast) [NCBI Gene 15977] {aka IFN-beta, IFNB, If1da1, Ifb}, Ccl4 (C-C motif chemokine ligand 4) [NCBI Gene 20303] {aka AT744.1, Act-2, MIP-1B, Mip1b, Scya4}, Ifngr1 (interferon gamma receptor 1) [NCBI Gene 15979] {aka CD119, IFN-gammaR, Ifgr, Ifngr, Nktar}, CD101 (CD101 molecule) [NCBI Gene 9398] {aka EWI-101, IGSF2, V7}, H2 (histocompatibility-2, MHC) [NCBI Gene 111364] {aka H-2, MHC-II}, Cd101 (CD101 antigen) [NCBI Gene 630146] {aka EWI-101, Gm1016, Gm734, Igsf2}, S100a8 (S100 calcium binding protein A8 (calgranulin A)) [NCBI Gene 20201] {aka 60B8Ag, B8Ag, CFAg, CP-10, Caga, MRP8}, Vegfa (vascular endothelial growth factor A) [NCBI Gene 22339] {aka L-VEGF, Vegf, Vpf}, Il2rg (interleukin 2 receptor, gamma chain) [NCBI Gene 16186] {aka CD132, [g]c, gamma(c), gc, p64} - **Diseases:** liver cancer (MESH:D006528), pancreatic cancer (MESH:D010190), experimental autoimmune encephalomyelitis (MESH:D004681), glioma (MESH:D005910), tissue damage (MESH:D017695), intracranial (MESH:D001932), acute lung injury (MESH:D055371), inflammatory (MESH:D007249), cancers (MESH:D009369), B16 melanoma (MESH:D008546), metabolic disorder (MESH:D008659), autoimmunity (MESH:D001327), lung cancer (MESH:D008175), breast cancer (MESH:D001943), hypoxia (MESH:D000860), colorectal carcinoma (MESH:D015179), Lewis lung carcinoma (MESH:D018827) - **Chemicals:** fat (MESH:D005223), LCPNS (-) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606] - **Cell lines:** OT-1 — Homo sapiens (Human), Lung small cell carcinoma, Cancer cell line (CVCL_7018), C57BL/6 — Mus musculus (Mouse), Transformed cell line (CVCL_C0MU), MC38 colorectal carcinoma — Mus musculus (Mouse), Mouse colon adenocarcinoma, Cancer cell line (CVCL_B288), BALB/c — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0184) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12313967/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12313967/full.md ## References 12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12313967/full.md --- Source: https://tomesphere.com/paper/PMC12313967