# From Skin Deep to Life-Threatening: A Case of Necrotizing Fasciitis Masquerading as Ecchymosis

**Authors:** Abigail Alorda, Sadman Chowdhury, Stephanie Cohen, Jovans Lorquet, Shayne Gue

PMC · DOI: 10.7759/cureus.87125 · Cureus · 2025-07-01

## TL;DR

A man with diabetes had a severe infection mistaken for a skin discoloration, leading to life-threatening complications requiring surgery and highlighting the need for early detection.

## Contribution

This case highlights the atypical presentation of necrotizing fasciitis in a diabetic patient and its rare complication of glomerulonephritis.

## Key findings

- Necrotizing fasciitis was misdiagnosed as ecchymosis due to subtle symptoms in a diabetic patient.
- The patient developed Staphylococcus-associated glomerulonephritis, a rare complication of S. aureus infection.
- Early recognition and surgical intervention were critical in managing the severe infection.

## Abstract

Necrotizing fasciitis (NF) is a rare but life-threatening infection characterized by rapid and extensive tissue necrosis. Early identification is often difficult, particularly when physical exam findings are subtle or atypical. We present the case of a man in his forties with poorly controlled type 2 diabetes mellitus who arrived at the emergency department after noticing discoloration and swelling of his right great toe. The patient had minimal pain but was noted to be hypotensive and tachycardic on arrival. Laboratory workup revealed hyperglycemia, hyponatremia, and elevated lactic acid. Imaging was negative for fracture or subcutaneous air. Due to the rapid progression of symptoms and abnormal vital signs, general surgery was consulted to evaluate for NF. The patient was admitted and subsequently developed a temperature of 106°F, requiring escalation of care. He underwent surgical debridement and amputation of the right hallux. Wound and blood cultures grew Staphylococcus aureus, and he was later diagnosed with Staphylococcus-associated glomerulonephritis, confirmed by renal biopsy. This case demonstrates the importance of early recognition and intervention in NF, particularly in patients with diabetic neuropathy, and highlights a rare complication of S. aureus infection.

## Linked entities

- **Diseases:** type 2 diabetes mellitus (MONDO:0005148), necrotizing fasciitis (MONDO:0004835)

## Full-text entities

- **Diseases:** necrosis (MESH:D009336), bacterial infection (MESH:D001424), anemia (MESH:D000740), liver disease (MESH:D008107), discoloration (MESH:D014075), Ecchymosis (MESH:D004438), gout (MESH:D006073), tenderness (MESH:D063806), hyperglycemia (MESH:D006943), loss of extremities (MESH:D003638), cellulitis (MESH:D002481), alcoholism (MESH:D000437), lymphadenopathy (MESH:D008206), hyponatremia (MESH:D007010), sepsis (MESH:D018805), death (MESH:D003643), deep vein thrombosis (MESH:D020246), hemorrhagic bullae (MESH:D001768), pain (MESH:D010146), febrile (MESH:D000071072), type 2 diabetes mellitus (MESH:D003924), NSTIs (MESH:D018461), NF (MESH:D019115), infectious (MESH:D003141), fracture (MESH:D050723), multiple organ failure (MESH:D009102), infection (MESH:D007239), hypotension (MESH:D007022), inflammation (MESH:D007249), SAGN (MESH:D005921), cancer (MESH:D009369), swelling of the toe (MESH:D000070592), erythema (MESH:D004890), Staphylococcus infection (MESH:D013203), edema (MESH:D004487), diabetes (MESH:D003920), lactic acidosis (MESH:D000140), septic shock (MESH:D012772), acute renal failure (MESH:D058186), peripheral vascular disease (MESH:D016491), chills (MESH:D023341), diabetic neuropathy (MESH:D003929), necrotizing skin (MESH:D012871), fever (MESH:D005334), neuropathy (MESH:D009422), renal complication (MESH:D007674), acute fracture (MESH:D000208)
- **Chemicals:** clindamycin (MESH:D002981), acetaminophen (MESH:D000082), metronidazole (MESH:D008795), sodium (MESH:D012964), insulin (MESH:D007328), vancomycin (MESH:D014640), cefepime (MESH:D000077723), creatinine (MESH:D003404), glucose (MESH:D005947), lactic acid (MESH:D019344)
- **Species:** Staphylococcus aureus (species) [taxon 1280], Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12313087/full.md

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Source: https://tomesphere.com/paper/PMC12313087