# Successful Conservative Management of Aplasia Cutis Congenita in a Preterm Neonate

**Authors:** Aleksandre Gvaladze, Tamar Gvalia, Konstantine Kvaratskhelia, David Gagua, Tinatin Gagua

PMC · DOI: 10.7759/cureus.87096 · Cureus · 2025-07-01

## TL;DR

A preterm baby with a rare skin condition was successfully treated without surgery or antibiotics, showing natural healing.

## Contribution

Demonstrates conservative management effectiveness for extensive ACC skin defects in neonates.

## Key findings

- Large ACC lesions in a newborn healed completely without surgical intervention.
- Conservative management avoided unnecessary antibiotics and surgeries in this case.
- Successful re-epithelialization occurred over several months.

## Abstract

Aplasia cutis congenita (ACC), type 5, is considered a rare condition and is typically recognized by symmetric skin defects visible at birth. Due to the limited number of documented cases, there are no established management guidelines, which can result in the use of unnecessary surgical or antibiotic interventions that may expose newborns to avoidable risks. We present a case from Gagua Clinic in Tbilisi, Georgia, involving a newborn with large, symmetric lesions on the trunk and around the umbilicus, which were managed conservatively and showed complete re-epithelialization over the course of a few months. This case highlights the successful conservative management of ACC with extensive skin defects, achieved without the need for surgery or antibiotics.

## Linked entities

- **Diseases:** Aplasia cutis congenita (MONDO:0007145)

## Full-text entities

- **Diseases:** placental abnormalities (MESH:D010922), clubbed hands or feet (MESH:D016110), congenital disorder (MESH:D009358), fetal growth restriction (MESH:D005317), placental infarction (MESH:D007238), infection (MESH:D007239), ischemia (MESH:D007511), fetus (MESH:D017490), hypotension (MESH:D007022), uteroplacental dysfunction (MESH:D006331), thromboembolic (MESH:D013923), bleeding (MESH:D006470), spastic paralysis (MESH:C538358), oligohydramnios (MESH:D016104), skin (MESH:D012871), labor (MESH:D048949), chromosomal abnormalities (MESH:D002869), necrosis (MESH:D009336), proteinuria (MESH:D011507), meningitis (MESH:D008580), ACC), type 5 (MESH:D004476), burn (MESH:D002056), hypertension (MESH:D006973), preeclampsia (MESH:D011225), seizure (MESH:D012640), developmental delay (MESH:D002658), DIC (MESH:D004211), Skin defect (MESH:D012868)
- **Chemicals:** hypochlorous acid (MESH:D006997), sodium chloride (MESH:D012965), magnesium sulfate (MESH:D008278), water (MESH:D014867), sulfadiazine (MESH:D013411), reactive oxygen species (MESH:D017382)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12312618/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12312618/full.md

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Source: https://tomesphere.com/paper/PMC12312618