# Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf of the DIVI neurology section

**Authors:** Rainer Kollmar, Hagen B. Huttner, Yigit Ozpeynirci, Christian Herweh, Jochen A. Sembill, Stefan Gerner, Michael Bender, Patrick Schramm, Ingo Schirotzek, Lisa Maeder, Anisa Myftiu, Marius Hartmann, Juergen Konczalla, Karsten Geletneky, Rainer Kram, Raimund Helbok, Joji B. Kuramatsu, Martin Welte, Amr Abdulazim, Emanuela Keller, Ferdinand Bohmann, Wolf-Rüdiger Schäbitz

PMC · DOI: 10.1186/s42466-025-00407-x · Neurological Research and Practice · 2025-07-30

## TL;DR

This paper presents a consensus-based protocol for the acute care of aneurysmal subarachnoid hemorrhage, developed by German-speaking neurointensivists and neuroradiologists to address clinical uncertainties and standardize treatment.

## Contribution

A practical, consensus-driven acute care protocol for aSAH, combining expert opinion and limited evidence to guide multidisciplinary management.

## Key findings

- Consensus was reached on diagnostic protocols, invasive monitoring, and blood pressure control for aSAH.
- Recommendations were provided for early intervention, nutrition, and fever prevention in aSAH patients.
- The consensus emphasized expert-derived strategies in areas with limited evidence, such as therapeutic hypothermia.

## Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a critical condition requiring multidisciplinary management, particularly in the intensive care setting. Despite existing guidelines, gaps in evidence and variability in practice remain, necessitating practical, consensus-driven recommendations for acute care and management.

To develop comprehensive, practical consensus statement for the acute management of aSAH, addressing high- and low-evidence areas, through a modified Delphi consensus approach among German-speaking neurointensivists and neuroradiologists.

Senior experts from neurology, neurosurgery, neurocritical care, and interventional neuroradiology were selected for their academic and clinical expertise. The consensus process included iterative rounds of Delphi surveys, a face-to-face meeting, and online discussions. Consensus statements were formulated based on literature review, expert input, and iterative validation, with a consensus threshold of ≥ 70% agreement.

The group reached consensus on key aspects of aSAH management, including diagnostic protocols, invasive monitoring, blood pressure and temperature control, prophylactic and therapeutic measures for vasospasm and delayed cerebral ischemia, nutrition, and mobilization. Specific guidance was provided for early surgical/endovascular intervention, invasive hemodynamic monitoring, enteral nutrition initiation, and fever prevention. The consensus emphasized evidence-informed strategies where available and expert-derived recommendations in areas lacking robust data, such as therapeutic hypothermia and multimodal monitoring.

This practical consensus statement provides a standardized approach to aSAH management, balancing guideline-based evidence with expert consensus to address clinical uncertainties. Due to the used methods and composition of the group, the results should be considered as a multi-institutional protocol of an experienced neurointensivist group, but certainly not as evidence based-guidelines. Adoption of this consensus may improve outcomes and harmonize care in the intensive management of aSAH.

## Full-text entities

- **Diseases:** impaired cerebral perfusion (MESH:D002547), cerebral infarction (MESH:D002544), ischemic neurologic deficits (MESH:D009461), Fever (MESH:D005334), ruptured aneurysm (MESH:D017542), pressure ulcers (MESH:D003668), stroke (MESH:D020521), acute brain injury (MESH:D001930), thromboembolism (MESH:D013923), elevated (MESH:D006937), DVT (OMIM:612862), inflammatory (MESH:D007249), renal insufficiency (MESH:D051437), hypotension (MESH:D007022), ICH (MESH:D002543), infections (MESH:D007239), Aneurysmal Subarachnoid Haemorrhage (MESH:D013345), infectious complications (MESH:D003141), ARDS (MESH:D012128), chronic hydrocephalus (MESH:D006849), pulmonary edema (MESH:D011654), pneumonia (MESH:D011014), ventriculitis (MESH:D058565), Hypovolemia (MESH:D020896), aneurysm (MESH:D000783), Seizures (MESH:D012640), brain damage (MESH:D001925), cerebral vasospasm (MESH:D020301), Hypothermia (MESH:D007035), Anemia (MESH:D000740), acute neurovascular injured (MESH:D000208), neurological deterioration (MESH:D009422), renal dysfunction (MESH:D007674), dehydration (MESH:D003681), septic shock (MESH:D012772), contusion (MESH:D003288), venous thromboembolism (MESH:D054556), intracranial hemorrhage (MESH:D020300), aneurysmatic hemorrhage (MESH:D006470), increased ICP (MESH:D019586), thrombosis (MESH:D013927), nausea (MESH:D009325), TTM (MESH:D000377), MCA-aneurysm (MESH:D020244), Ischaemia (MESH:D007511), spasms (MESH:D013035), deep venous thrombosis (MESH:D020246), respiratory instability (MESH:D012131), hematomas (MESH:D006406), cerebral hypoxia (MESH:D002534), DCI (MESH:D002545), diarrhea (MESH:D003967), Hypertension (MESH:D006973), epilepsy (MESH:D004827), critically ill (MESH:D016638)
- **Chemicals:** lactate (MESH:D019344), heparinoids (MESH:D006496), enoxaparin (MESH:D017984), heparin (MESH:D006493), metamizole (MESH:D004177), Nimodipine (MESH:D009553), O2 (MESH:D010100), pyruvate (MESH:D019289), glucose (MESH:D005947), adenosine triphosphate (MESH:D000255), TXA (MESH:D014148), Comaneci (-), glycerol (MESH:D005990), glutamate (MESH:D018698), norepinephrine (MESH:D009638), magnesium (MESH:D008274), blood glucose (MESH:D001786), paracetamol (MESH:D000082)
- **Species:** Bos taurus (bovine, species) [taxon 9913], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12312491/full.md

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Source: https://tomesphere.com/paper/PMC12312491