# Retinal parameter analysis and diagnostic potential exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography

## TL;DR

This study explores non-invasive ultra-widefield fundus photography for early diagnosis of FEVR by analyzing retinal parameters and their changes during disease progression.

## Contribution

The study introduces a non-invasive diagnostic approach using UWFFP and automated retinal parameter analysis for FEVR detection and staging.

## Key findings

- 25 retinal parameters showed significant differences between FEVR patients and controls, with some parameters showing diagnostic potential.
- As FEVR progressed, optic disc and cup diameters decreased, while optic disc-to-macula distance and vascular parameters declined.
- UWFFP and automated analysis offer promising tools for early FEVR diagnosis with structural and vascular markers.

## Abstract

Familial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra-widefield fundus photography (UWFFP), this research explored both the diagnostic potential of integrated retinal parameters for the detection of FEVR, and their characteristic changes during the early stage progression.

Retinal parameters were systematically extracted and quantified from UWFFP of 114 FEVR patients and 114 matched controls using the EVision AI cloud platform. Comparative statistical analyses were performed to identify significant intergroup differences between FEVR and control cohorts, and assess intra-group variations among FEVR subgroups. Based on parameters that showed significant differences between the FEVR group and the control group and had an impact on the FEVR group, a diagnostic model was constructed. Receiver operating characteristic (ROC) curves were plotted to determine the diagnostic potential of these parameters. In addition, subgroup analysis within the FEVR group was conducted to clarify the relationship between retinal parameters and disease staging.

Significant differences were observed in 25 retinal parameters between the FEVR group and the control group, with the horizontal cup-to-disc ratio, vertical cup-to-disc ratio, optic disc-to-macula distance, and vascular density demonstrating potential diagnostic efficacy. Subgroup analysis within the FEVR group revealed that as the disease stage advanced and severity increased, the optic disc and cup diameters decreased, the optic disc-to-macula distance increased, and the vascular fractal dimension and vascular density parameters declined.

UWFFP and automated retinal parameter analysis offer promising tools for early FEVR diagnosis, with specific structural and vascular markers providing diagnostic potential. Further large-scale studies are needed to validate these findings and refine diagnostic models.

The online version contains supplementary material available at 10.1186/s40942-025-00716-y.