# An Unexpected Diagnosis of Kawasaki Disease in a Three-Month-Old Infant: A Diagnostic Trap

**Authors:** Olfa Asbik, Ikram El Hachmi, Aziza Elouali, Maria Rkain, Abdeladim Babakhouya

PMC · DOI: 10.7759/cureus.87088 · Cureus · 2025-07-01

## TL;DR

This case report highlights the difficulty of diagnosing Kawasaki disease in infants under six months, emphasizing the need for early detection to prevent heart complications.

## Contribution

The paper presents a rare case of Kawasaki disease diagnosed in a three-month-old infant, emphasizing diagnostic challenges in this age group.

## Key findings

- The infant's initial symptoms were misattributed to pyelonephritis, delaying proper diagnosis.
- Kawasaki disease in infants under six months often presents with atypical symptoms, complicating diagnosis.
- Early echocardiography and high clinical suspicion are essential for timely management in young infants.

## Abstract

Kawasaki disease (KD) is an acute systemic vasculitis predominantly affecting young children and can lead to serious cardiac complications if not diagnosed and treated promptly. Diagnosing KD in infants younger than six months is challenging due to atypical or incomplete presentations, increasing the risk of cardiovascular complications. The purpose of this case report was to detail the clinical presentation, laboratory findings, and cardiac outcomes in a patient diagnosed with KD during the first three months of life. The infant’s initial symptoms were misleading, as the prolonged fever was initially attributed to pyelonephritis, leading to an antibiotic treatment that did not resolve the fever. The overlap of KD symptoms with other febrile illnesses and the subtle or absent classical signs of KD in this age group often complicate the diagnosis. This case underscores the importance of considering KD in infants under six months with persistent fever and highlights diagnostic challenges, including misinterpretation of symptoms. Early echocardiography and high clinical suspicion are crucial for timely diagnosis and management to prevent severe cardiac complications in this vulnerable age group.

## Linked entities

- **Diseases:** Kawasaki disease (MONDO:0012727), pyelonephritis (MONDO:0006939)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** cardiac complications (MESH:D006331), hemorrhagic (MESH:D006470), edema (MESH:D004487), KD (MESH:D009080), febrile illnesses (MESH:D005334), dehydration (MESH:D003681), coronary lesions (MESH:D003327), cheilitis (MESH:D002613), inflammatory (MESH:D007249), desquamation (MESH:D017490), pyuria (MESH:D011776), systemic vasculitis (MESH:D056647), aneurysm (MESH:D000783), Coronary Arteries (MESH:D003324), allergic reaction (MESH:D004342), pyelonephritis (MESH:D011704), urinary tract infection (MESH:D014552), coronary artery aneurysms (MESH:D003323), otitis media (MESH:D010033), irritable (MESH:D001523), anemia (MESH:D000740), cardiovascular complications (MESH:D002318), maculopapular rash (MESH:D005076)
- **Chemicals:** acetylsalicylic acid (MESH:D001241), vitamin K antagonist (-), clopidogrel (MESH:D000077144)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12311875/full.md

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Source: https://tomesphere.com/paper/PMC12311875