# Effectiveness of Magnesium Sulfate for Post-Cesarean Pain Control: A Double-blind Clinical Trial: Magnesium Sulfate for Post-cesarean Pain

## TL;DR

This study found that magnesium sulfate does not significantly reduce pain or improve analgesia after repeat cesarean sections.

## Contribution

The study provides new evidence on the ineffectiveness of magnesium sulfate for post-cesarean pain control in a double-blind trial.

## Key findings

- No significant difference in pain scores between magnesium sulfate and control groups at 6, 12, 18, and 24 hours post-surgery.
- No significant effect of magnesium sulfate on analgesia duration or pethidine requirement.
- No notable complications were observed in either group during recovery.

## Abstract

The use of magnesium sulfate as a part of analgesia has been used in recent
years. The purpose of this research is to investigate the effectiveness of
magnesium sulfate in controlling pain after elective repeat cesarean section
under spinal anesthesia.

In this double-blind study, 78 women who were candidates for cesarean section
were randomly selected and divided into two groups of control and
intervention of 39 people. Before spinal anesthesia, in the intervention
group was injected 50 mg/kg of magnesium sulfate intravenously, and in the
control group was injected with the same volume of normal saline. Pain
intensity was assessed using the Visual Analogue Scale at 6, 12, 18 and 24
hours after the surgery operation and was recorded in a checklist along with
vital signs and possible complications. The results were statistically
analyzed using version 25 SPSS statistical software.

There was no significant difference between the intervention and control
groups in the presence of complications during recovery time and up to 24
hours after surgery (P0.05). The pain score during the first 6 hours after
surgery was equal to 8.56±1.51 in the intervention group and 8.21±1.15 in
the control group. At 24 hours after surgery, this amount decreased to
4.23±1.08 in the intervention group and 4.49±0.79 in the control group.
Although there was a difference in pain scores between the intervention and
control groups up to 24 hours after surgery, this difference was not
statistically significant (P0.05).

This study showed that the administration or non-administration of magnesium
sulfate has no effect on increasing the time of postpartum analgesia and
reducing the need for pethidine.