# MEAanalysis: an open-source R package for downstream visualization of AxIS navigator multi-electrode array burst data at the single-electrode level

**Authors:** Emily A Gordon, David L Bennett, Georgios Baskozos, Maddalena Comini

PMC · DOI: 10.1093/bioadv/vbaf160 · Bioinformatics Advances · 2025-07-03

## TL;DR

MEAanalysis is an open-source R package that helps visualize MEA data at the single-electrode level, improving understanding of cell network activity.

## Contribution

It introduces single-electrode-level visualization of burst data after AxIS Navigator processing.

## Key findings

- The package enables detailed spatiotemporal analysis of excitable cell networks.
- It improves reproducibility and understanding of MEA data.
- User feedback will guide future development.

## Abstract

Multi-electrode array (MEA) generate electrophysiological data that can be used to functionally characterize excitable cells. MEA data can be complex to analyse in a reproducible manner, with current data analysis tools often calculating parameters at the whole-well level. Here we present MEAanalysis, an open-source R package [GPL (≥2)] able to visualize burst parameters at the single electrode level downstream of AxIS Navigator software (Axion BioSystems) processing, thus increasing our understanding of an excitable cell network’s spatiotemporal variability.

The package is hosted on and can be installed from the following GitHub repository: https://github.com/egordon2/MEA-analysis-package. User feedback provided via email or the GitHub issues tab will inform cycles of development.

## Full-text entities

- **Diseases:** toxicity (MESH:D064420), autism (MESH:D001321), pain disorders (MESH:D013001), overdose of anaesthetic (MESH:D062787), amyotrophic lateral sclerosis (MESH:D000690), neurological disease (MESH:D020271)
- **Chemicals:** B27 (-), L-cysteine (MESH:D003545), penicillin (MESH:D010406), Glutamax (MESH:C054122), EDTA (MESH:D004492), CaCl2 (MESH:D002122), KCl (MESH:D011189), spike (MESH:C010346), streptomycin (MESH:D013307), CO2 (MESH:D002245)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12311347/full.md

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Source: https://tomesphere.com/paper/PMC12311347