# Onychomycosis Caused by Aspergillus niger in an Immunocompetent Young Female: A Case Report of a Rare Presentation

**Authors:** Abdulrahman Saleh Aldairi, Faris Alsaedi, Homaid Alotaibi

PMC · DOI: 10.7759/cureus.87003 · Cureus · 2025-06-29

## TL;DR

A 25-year-old healthy woman developed a rare fungal nail infection caused by Aspergillus niger, typically seen in people with weakened immune systems.

## Contribution

Reports an unusual case of onychomycosis in an immunocompetent individual caused by Aspergillus niger.

## Key findings

- Aspergillus niger can cause onychomycosis in immunocompetent individuals.
- The infection presented as a single fingernail involvement in a young female.
- This case highlights the expanding clinical spectrum of non-dermatophyte mold infections.

## Abstract

Onychomycosis is a fungal infection of the nail that may result from dermatophytes, non-dermatophyte molds, or yeasts. Among non-dermatophyte molds, Aspergillus niger is a recognized species with the potential to cause nail infections. While such infections were traditionally reported in immunocompromised individuals, they have also been increasingly observed in immunocompetent hosts. This condition carries clinical importance due to its potential for recurrence and resistance to treatment. Herein, we present a case of a 25-year-old immunocompetent female with a single fingernail onychomycosis caused by A. niger.

## Linked entities

- **Diseases:** onychomycosis (MONDO:0001628)
- **Species:** Aspergillus niger (taxon 5061)

## Full-text entities

- **Diseases:** trauma (MESH:D014947), Aspergillus nail infection (MESH:D001228), nail abnormalities (MESH:D009264), diabetes mellitus (MESH:D003920), hyperkeratosis (MESH:D017488), Aspergillus onychomycosis (MESH:D014009), bacterial infections (MESH:D001424), nail deformity (MESH:D009260), fungal (MESH:D009181), infection (MESH:D007239), toenail pigmentation (MESH:C564384), NDMs (MESH:D003881)
- **Chemicals:** SDA (-), glucose (MESH:D005947), terbinafine (MESH:D000077291), KOH (MESH:C029943), amorolfine (MESH:C038974), itraconazole (MESH:D017964)
- **Species:** Homo sapiens (human, species) [taxon 9606], Aspergillus ustus (species) [taxon 40382], Scopulariopsis brevicaulis (arsenic fungus, species) [taxon 561152], A. flavus [taxon 315677], Aspergillus fumigatus (species) [taxon 746128], Aspergillus niger (species) [taxon 5061], Trichophyton rubrum (species) [taxon 5551], Aspergillus terreus (species) [taxon 33178], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Aspergillus glaucus (species) [taxon 41413], Acremonium [taxon 1036747]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12310977/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12310977/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12310977/full.md

---
Source: https://tomesphere.com/paper/PMC12310977