# Impact of local therapy in metastatic renal cell carcinoma during medical treatment in a retrospective analysis

## TL;DR

This study examines how local therapy affects survival in kidney cancer patients receiving medical treatment, finding potential benefits in specific cases.

## Contribution

The study provides the largest analysis of local therapy use during medical treatment for metastatic renal cell carcinoma.

## Key findings

- Overall survival was not significantly better with local therapy during medical treatment.
- Patients receiving local therapy after six months of medical treatment had improved survival.
- Oligoprogression was associated with better outcomes compared to systemic progression.

## Abstract

Current guidelines on treatment of metastatic renal cell carcinoma (mRCC) suggest an emerging role of local therapy (LT). Still there is a lack of data which patients may benefit from additional LT once medical treatment (MT) is initiated. We retrospectively aim to characterize LT in patients with mRCC who underwent LT while receiving MT. 315/401 mRCC patients were eligible, thereof 163 (51.7%) received LT during MT (LT( +)), while 152 (48.3%) received only MT (LT(-)). Radiotherapy (49.1%) and surgery (41.7%) were the most frequently administered LT modalities. Overall survival (OS) was not superior in LT( +) vs. LT(-) (35.9, (95%-CI [confidence interval]: 29.8–42.0) vs. 20.3, (95%-CI: 10.3–30.3) months, log-rank p = 0.117). However, in a subgroup analysis the duration of MT prior to initiation of LT (≤ 6 months 24.1 (95%-CI: 18.6–29.6) vs. > 6 months: 43.0 (95%-CI: 32.2–36.2) months, log-rank p = 0.005) and the type of progression (oligoprogression: 44.0 (95%-CI: 31.5–56.5) vs. systemic progression: 29.6 (95%-CI: 23.4–35.8) months, log-rank p = 0.03) were associated with improved OS. We present the largest analysis of LT during MT. Our study has enhanced our understanding of LT utilization in mRCC after MT is already initiated. Ultimately, the inclusion of LT could improve OS in selected patients receiving MT.