# Advancements and trends in digestive system autotransplantation: a bibliometric and visualization analysis

**Authors:** Aimitaji Abulaiti, Talaiti Tuergan, Alimu Tulahong, Ruiqing Zhang, Yingmei Shao, Tuerganaili Aji

PMC · DOI: 10.3389/fmed.2025.1537446 · Frontiers in Medicine · 2025-07-17

## TL;DR

This paper analyzes research trends in digestive system autotransplantation, showing growth in publications and highlighting key contributors and areas of focus.

## Contribution

The study provides a comprehensive bibliometric and visualization analysis of digestive system autotransplantation research trends.

## Key findings

- Publication volume increased steadily from 2004 to 2015, then declined after 2016.
- The United States leads in research output, followed by China.
- High-frequency keywords include autologous transplantation and chronic pancreatitis.

## Abstract

Digestive system autotransplantation is an emerging surgical technique used to treat complex digestive diseases.

This study conducted a bibliometric analysis of 748 publications from the Web of Science Core Collection (WoSCC) database, using VOSviewer and CiteSpace tools to map research trends, author contributions, and institutional collaborations. Articles were selected based on their relevance to digestive system autotransplantation, focusing on autologous liver, pancreatic, and small intestine transplantation. The analysis included publication volume, citation counts, key authors, leading journals, and keyword co-occurrence.

The analysis revealed a steady rise in publications between 2004 and 2015, followed by a gradual decline after 2016. The United States leads in research output, accounting for 40.11% of publications, followed by China. The leading institutions are predominantly based in the United States, with the University of Minnesota System producing the most publications. High-frequency keywords include autologous transplantation, pancreatic transplantation, chronic pancreatitis (CP), and postoperative complications.

Digestive system autotransplantation is a promising approach for complex cases. Continued interdisciplinary collaboration and focus on clinical outcomes will drive future advancements.

## Linked entities

- **Diseases:** chronic pancreatitis (MONDO:0005003)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 397415]
- **Diseases:** hyperglycemia (MESH:D006943), ischemic (MESH:D002545), brittle diabetes (MESH:D003922), diarrhea (MESH:D003967), liver tumors (MESH:D008113), SBS (MESH:D012778), complications (MESH:D008107), sphincter of Oddi dysfunction (MESH:D046628), pain (MESH:D010146), CP (MESH:D050500), parasitic disease (MESH:D010272), liver cancer (MESH:D006528), ischemia reperfusion injury (MESH:D015427), malnutrition (MESH:D044342), graft dysfunction (MESH:D055031), pancreatic tumors (MESH:D010190), end-stage chronic pancreatitis (MESH:D007676), tumor (MESH:D009369), inflammation (MESH:D007249), injury (MESH:D014947), HAE (MESH:D004444), infection (MESH:D007239), ischemia (MESH:D007511), hereditary pancreatitis (MESH:C537262), hepatic hydatid disease (MESH:D004443), digestive diseases (MESH:D004066), pancreatic (MESH:D010195), cystic fibrosis (MESH:D003550), small intestine diseases (MESH:D007410), hepatic hemangioma (MESH:D006391), vascular occlusion (MESH:D008641), insulin independence (MESH:D007333), intestinal tumors (MESH:D007414), bleeding (MESH:D006470), diabetes (MESH:D003920), pancreas divisum (MESH:D000092142), thrombosis (MESH:D013927), exocrine insufficiency (MESH:D010188)
- **Chemicals:** C-peptide (MESH:D002096), indocyanine green (MESH:D007208), alcohol (MESH:D000438), TP (-), dexmedetomidine (MESH:D020927), glucose (MESH:D005947)
- **Species:** Sus scrofa (pig, species) [taxon 9823], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12310704/full.md

## References

49 references — full list in the complete paper: https://tomesphere.com/paper/PMC12310704/full.md

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Source: https://tomesphere.com/paper/PMC12310704