# Interactive effects of prenatal adversity and COVID-19 hardship on youth psychological distress: a longitudinal study

**Authors:** Yifan Wang, Xinni Wang, Chloé Voyer, Alain Brunet, François Freddy Ateba, Ashley Wazana, David P. Laplante

PMC · DOI: 10.3389/frcha.2025.1581135 · Frontiers in Child and Adolescent Psychiatry · 2025-07-17

## TL;DR

This study finds that youth exposed to early adversity may be more resilient to pandemic-related stress, showing how early life challenges can help buffer against later psychological distress.

## Contribution

The study introduces a novel perspective on how early adversity may foster resilience during later crises like the pandemic.

## Key findings

- Youth who experienced high perinatal maternal adversity showed resilience during pandemic disruptions.
- Youth-reported pandemic hardship, especially daily life changes, predicted psychological distress and PTSD symptoms.
- Interactive effects suggest that early adversity may mitigate distress during later crises.

## Abstract

The COVID-19 pandemic resulted in severe loss of life and increased anxiety as well as fear worldwide. This study explored whether pre-pandemic exposure to varying levels of perinatal maternal adversity coupled with pandemic-related experiences are related to youth distress levels.

Data from 119 youth (aged 9–17) and their mothers were analyzed to assess the interactive effects of perinatal maternal adversity and pandemic-related objective hardship on youth psychological distress.

Youth-reported hardship models consistently explained more variance in their psychological distress. Youth-reported hardship, specifically daily life changes, predicted psychological distress, including PTSD symptoms and peritraumatic experiences during the pandemic.

Youths exposed to high perinatal maternal socio-environmental adversity demonstrated resilience when faced with pandemic disruptions, suggesting that alignment between early adversity and later stress can mitigate distress during crises.

## Full-text entities

- **Diseases:** alcohol and substance abuse (MESH:D019966), and/or illness (MESH:D002908), Mental Disorders (MESH:D001523), death in family, accident (OMIM:115080), dissociation (MESH:D004213), COVID (MESH:D000086382), Distress (MESH:D012128), sick (MESH:D008881), infected (MESH:D007239), FA (MESH:C565561), panic (MESH:D016584), PTSD (MESH:D013313), Depression (MESH:D003866), Anxiety (MESH:D001007), criminal involvement (MESH:C564676), maternal (MESH:D000079262), affective symptoms (MESH:D019964), internalizing problems (MESH:D000082122), death (MESH:D003643)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12310598/full.md

## References

51 references — full list in the complete paper: https://tomesphere.com/paper/PMC12310598/full.md

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Source: https://tomesphere.com/paper/PMC12310598