# Aureobasidium Melanogenum as an Uncommon Pathogen Causing Skin and Soft Tissue Infection: A Case Report and Literature Review

**Authors:** Gopi Patel, Shelly Sclater, Pooja Gurram, Sai Chintalapati

PMC · DOI: 10.7759/cureus.87056 · Cureus · 2025-06-30

## TL;DR

A rare fungus called Aureobasidium melanogenum caused a skin infection in a healthy person, showing it can affect more people than previously thought.

## Contribution

This is the first reported case of A. melanogenum causing infection in an immunocompetent individual.

## Key findings

- A. melanogenum was identified as the cause of skin and soft tissue infection in an immunocompetent patient.
- The infection was successfully treated with intravenous micafungin over two weeks.
- The case suggests A. melanogenum should be considered in community-acquired infections, not just in immunocompromised individuals.

## Abstract

Aureobasidium melanogenum is an emerging pathogen of growing importance in medical literature. It is a dematiaceous fungus with a propensity to cause opportunistic infections in immunocompromised hosts. However, we present a case of an immunocompetent patient who developed a skin and soft-tissue infection caused by A. melanogenum. The pathogen was identified at a reference laboratory at the University of Texas (UT), San Antonio, Texas, using phenotypic and DNA sequencing techniques. The patient was successfully treated with a two-week course of intravenous micafungin. This case highlights the need to recognize such emerging organisms as potential causes for common community-acquired infections requiring prompt treatment rather than considering them as potential environmental contaminants.

## Linked entities

- **Chemicals:** micafungin (PubChem CID 477468)
- **Species:** Aureobasidium melanogenum (taxon 46634)

## Full-text entities

- **Diseases:** leukocytosis (MESH:D007964), edema (MESH:D004487), tissue (MESH:D017695), chronic osteomyelitis (MESH:D010019), chills (MESH:D023341), Skin (MESH:D012871), Infectious Diseases (MESH:D003141), synovial thickening (MESH:D013585), A. melanogenum infection (MESH:D007239), opportunistic infections (MESH:D009894), bloodstream infections (MESH:D018805), death (MESH:D003643), pain (MESH:D010146), tenderness (MESH:D063806), diabetes mellitus (MESH:D003920), toxicities (MESH:D064420), SSTIs (MESH:D018461), fungemia (MESH:D016469), injury (MESH:D014947), Fungal (MESH:D009181), knee injury (MESH:D007718), pulmonary, and peritoneal infections (MESH:D010538), fatigue (MESH:D005221)
- **Chemicals:** CVC (MESH:C506967), Echinocandins (MESH:D054714), vancomycin (MESH:D014640), clofazimine (MESH:D002991), acid (MESH:D000143), omadacycline (MESH:C000591640), tigecycline (MESH:D000078304), cefepime (MESH:D000077723), imipenem (MESH:D015378), ribonucleic (-), Fluconazole (MESH:D015725), micafungin (MESH:D000077551), amphotericin (MESH:D000666), amikacin (MESH:D000583)
- **Species:** Mycobacteroides abscessus subsp. bolletii (subspecies) [taxon 319705], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Aureobasidium (genus) [taxon 5579], Aureobasidium melanogenum (species) [taxon 46634], Homo sapiens (human, species) [taxon 9606], Mycobacteroides abscessus (species) [taxon 36809], Human immunodeficiency virus 1 (no rank) [taxon 11676], Candida [taxon 1535326]

## Full text

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## Figures

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## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12310274/full.md

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Source: https://tomesphere.com/paper/PMC12310274