# circ-miR-524 accelerates the growth of liver cancer cells by inducing DNA damage repair through K-RAS

**Authors:** Yanan Lu, Dongdong Lu

PMC · DOI: 10.1016/j.gendis.2025.101675 · Genes & Diseases · 2025-05-08

## Full-text entities

- **Genes:** MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, ETS2 (ETS proto-oncogene 2, transcription factor) [NCBI Gene 2114] {aka ETS2IT1}, PCNA (proliferating cell nuclear antigen) [NCBI Gene 5111] {aka ATLD2}, NR2F6 (nuclear receptor subfamily 2 group F member 6) [NCBI Gene 2063] {aka EAR-2, EAR2, ERBAL2}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit) [NCBI Gene 56339] {aka IME4, M6A, MT-A70, Spo8, hMETTL3}, JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 3726] {aka AP-1}, RIPK1 (receptor interacting serine/threonine kinase 1) [NCBI Gene 8737] {aka AIEFL, IMD57, RIP, RIP-1, RIP1}, POTEF (POTE ankyrin domain family member F) [NCBI Gene 728378] {aka A26C1B, POTE2alpha, POTEACTIN}, MIR524 (microRNA 524) [NCBI Gene 574478] {aka MIRN524, hsa-mir-524, mir-524}, H2AX (H2A.X variant histone) [NCBI Gene 3014] {aka H2A.X, H2A/X, H2AFX}
- **Diseases:** Cancer (MESH:D009369), tumorigenesis (MESH:D063646), carcinogenic (MESH:D011230), HCC (MESH:D006528)
- **Chemicals:** rucaparib (MESH:C531549), CCK8 (MESH:D012844)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** Hep3B — Homo sapiens (Human), Childhood hepatocellular carcinoma, Cancer cell line (CVCL_0326)

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## References

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Source: https://tomesphere.com/paper/PMC12310062