# Giant adrenal calcification: rare case report and literature review

**Authors:** Zaiqing Jiang, Yunfeng Li, Kai Zhao, Xinbao Yin, Ke Wang, Zongliang Zhang

PMC · DOI: 10.1016/j.eucr.2025.103131 · Urology Case Reports · 2025-07-19

## TL;DR

A rare case of a very large adrenal calcification in a woman is reported, with successful surgical removal and no recurrence after 18 months.

## Contribution

This is the largest documented case of idiopathic giant adrenal calcification, highlighting the need for better diagnostic and management guidelines.

## Key findings

- An 8.5 × 7.0 × 5.0 cm adrenal mass was successfully removed via laparoscopic surgery.
- No recurrence was observed at the 18-month follow-up.
- The case underscores the lack of evidence-based guidelines for this rare condition.

## Abstract

We report the largest documented case of idiopathic giant adrenal calcification in a middle-aged woman, incidentally detected during imaging. Preoperative CT revealed an 8.5 × 7.0 × 5.0 cm left adrenal mass. Retroperitoneal laparoscopic adrenalectomy was successfully performed, with no recurrence at 18-month follow-up. This rare condition lacks evidence-based guidelines, necessitating multicenter studies to refine diagnosis and management.

## Full-text entities

- **Diseases:** hemorrhage (MESH:D006470), vascular abnormalities (MESH:D014652), infarction (MESH:D007238), tuberculosis (MESH:D014376), adrenal hemorrhage (MESH:D014884), schwannomas (MESH:D009442), cortical adenomas (MESH:D018246), adrenocortical carcinoma (MESH:D018268), embryonic developmental abnormalities (MESH:D018236), abdominal pain (MESH:D015746), adrenal disorders of calcium metabolism (MESH:D002128), calcified (MESH:D018333), blood loss (MESH:D016063), hypertension (MESH:D006973), endocrine hormonal disturbances (MESH:D004700), Adrenal calcification (MESH:D002114), adrenal hemangioma (MESH:D006391), inflammatory responses (MESH:D018746), infectious lesions (MESH:D003141), malignancies (MESH:D009369), adrenal lesions (MESH:D000307), myelolipomas (MESH:D018209), left adrenal mass (MESH:C536030), lumbar pain (MESH:D010146), necrosis (MESH:D009336), adrenal cysts (MESH:C538015), cyst (MESH:D003560), pheochromocytomas (MESH:D010673), Idiopathic adrenal calcification (MESH:C537440), adrenal tumors (MESH:D000310), liposarcoma (MESH:D008080)
- **Chemicals:** calcium (MESH:D002118), Calcium salt (-), phosphorus (MESH:D010758)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12310058/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12310058/full.md

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Source: https://tomesphere.com/paper/PMC12310058