# A Case Report of Clozapine-Induced Cardiomyopathy

**Authors:** Gourav Gourisaria, Navin Sumanasan, Goksu Ozen, Thejas Swaroop Konduru, Pradeep Karunakaran Thozhuthumparambil

PMC · DOI: 10.7759/cureus.87032 · Cureus · 2025-06-30

## TL;DR

This case report describes a patient who developed a rare heart condition after taking clozapine, a high-risk antipsychotic drug.

## Contribution

The report adds a new clinical case highlighting clozapine's rare but serious side effect of cardiomyopathy.

## Key findings

- A 42-year-old male developed cardiomyopathy while on clozapine.
- The patient showed symptoms like tachycardia and drowsiness.
- The condition was likely caused by clozapine use.

## Abstract

Clozapine is an antipsychotic medication prescribed for patients who do not respond to or cannot tolerate standard antipsychotic treatments. It is also used to manage psychosis associated with Parkinson’s disease. As a high-risk drug, clozapine requires strict monitoring. A rare but serious side effect is cardiomyopathy, which necessitates discontinuation of the medication. This report presents the case of a 42-year-old male patient admitted with recurrent falls and urinary sepsis while on clozapine. He exhibited persistent tachycardia and drowsiness and was diagnosed with cardiomyopathy, likely induced by clozapine.

## Linked entities

- **Chemicals:** clozapine (PubChem CID 135398737)
- **Diseases:** cardiomyopathy (MONDO:0004994), Parkinson’s disease (MONDO:0005180), psychosis (MONDO:0005485)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, CRP [NCBI Gene 20468888], CYP1A2 (cytochrome P450 family 1 subfamily A member 2) [NCBI Gene 1544] {aka CP12, CYPIA2, P3-450, P450(PA)}, CYP3A4 (cytochrome P450 family 3 subfamily A member 4) [NCBI Gene 1576] {aka CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4}
- **Diseases:** agranulocytosis (MESH:D000380), pulmonary embolism (MESH:D011655), schizophrenia (MESH:D012559), coronary plaques (MESH:D003323), urinary sepsis (MESH:D018805), tachycardia (MESH:D013610), orthostatic hypotension (MESH:D007024), Escherichia coli infection (MESH:D004927), cardiac complications (MESH:D006331), metabolic syndrome (MESH:D024821), Parkinson's disease (MESH:D010300), myocarditis (MESH:D009205), infection (MESH:D007239), psychosis (MESH:D011618), systole (MESH:D000092244), coronary artery disease (MESH:D003324), cardiac or abdominal symptoms (MESH:D000007), myocardial infarction (MESH:D009203), type 2 respiratory failure (MESH:D012131), sinus tachycardia (MESH:D013616), left ventricular systolic dysfunction (MESH:D018487), chest discomfort (MESH:D013898), psychiatric (MESH:D001523), selenium deficiency (MESH:D007153), fatigue (MESH:D005221), QTc interval prolongation (MESH:D008133), HNDC (MESH:C536231), Cardiomyopathy (MESH:D009202), hypoxia (MESH:D000860), type 2 diabetes (MESH:D003924), infarction (MESH:D007238), dyspnea (MESH:D004417)
- **Chemicals:** Valproic acid (MESH:D014635), Clozapine (MESH:D003024), dapagliflozin (MESH:C529054), atorvastatin (MESH:D000069059), gentamicin (MESH:D005839), losartan (MESH:D019808), oxygen (MESH:D010100), olanzapine (MESH:D000077152), metformin (MESH:D008687)
- **Species:** Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Escherichia coli (E. coli, species) [taxon 562], Respiratory syncytial virus (no rank) [taxon 12814], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12309623/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12309623/full.md

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Source: https://tomesphere.com/paper/PMC12309623