# The influence of renal function on surgical outcomes of vitrectomy in patients with proliferative diabetic retinopathy

## TL;DR

This study found that poor kidney function does not worsen surgical outcomes for vitrectomy in patients with a type of diabetic eye disease.

## Contribution

The study demonstrates that impaired renal function does not negatively impact vitrectomy outcomes in proliferative diabetic retinopathy patients.

## Key findings

- Patients with impaired renal function showed greater visual acuity improvement after surgery at multiple follow-up times.
- No significant differences in surgical procedures or complications were observed between the groups.
- Postoperative visual acuity outcomes were similar between groups despite initial differences.

## Abstract

To investigate the influence of renal function on the surgical outcomes of vitrectomy in patients with proliferative diabetic retinopathy (PDR).

A secondary analysis was conducted on data from a retrospective cohort study.

A total of 128 eyes with PDR that underwent pars plana vitrectomy (PPV) and were followed up for at least 2 years were enrolled, including 65 eyes in the impaired renal function (IRF) group and 63 eyes in the normal renal function (NRF) group. No significant between-group differences were observed in the proportion of cataract surgery (p = 0.722), intraoperative retinal photocoagulation (p = 0.476), gas tamponade (p = 0.932), silicone oil tamponade (p = 0.254), retinal dialysis and/or iatrogenic retinal breaks (p = 0.447), and 23- or 25-gauge (G) microincision vitrectomy surgery (MIVS) (p = 0.160). Similarly, intergroup comparisons showed no significant differences in the proportion of reoperation (p = 0.883), postoperative vitreous hemorrhage (VH) and/or retinal detachment (RD) (p = 0.919), postoperative neovascular glaucoma (NVG) (p = 0.600), and postoperative diabetic macular edema (DME) (p = 0.794). Notably, the IRF group had worse baseline best corrected visual acuity (BCVA) (p = 0.039) and showed greater BCVA improvement at 3 months (p = 0.008), 6 months (p = 0.047), 1 year (p = 0.007), 2 years (p = 0.003), 3 years (p = 0.009), and 4 years (p = 0.024) after surgery. However, there was no significant difference in postoperative BCVA between the two groups at each follow-up time (all p > 0.05).

Renal insufficiency does not adversely affect the surgical outcomes of PPV in patients with PDR.