# The Rho/MRTF-pirin axis: a promising target for overcoming melanoma drug resistance

**Authors:** Xiaoyan Chen, Junfeng Zhang, Bao Zhang, Zhi Li

PMC · DOI: 10.3389/fphar.2025.1571933 · Frontiers in Pharmacology · 2025-07-16

## Full-text entities

- **Genes:** Casp3 (caspase 3) [NCBI Gene 12367] {aka A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32}, MAP2K7 (mitogen-activated protein kinase kinase 7) [NCBI Gene 5609] {aka JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, NRAS (NRAS proto-oncogene, GTPase) [NCBI Gene 4893] {aka ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6}, RHO (rhodopsin) [NCBI Gene 6010] {aka CSNBAD1, OPN2, RP4}, MRTFA (myocardin related transcription factor A) [NCBI Gene 57591] {aka BSAC, MAL, MKL, MKL1, MRTF-A}, Acta2 (actin alpha 2, smooth muscle, aorta) [NCBI Gene 11475] {aka 0610041G09Rik, Actvs, SMAalpha, SMalphaA, a-SMA, alphaSMA}, PIR (pirin) [NCBI Gene 8544], BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, Parp1 (poly (ADP-ribose) polymerase family, member 1) [NCBI Gene 11545] {aka 5830444G22Rik, ARTD1, Adprp, Adprt1, PARP, PPOL}, Mki67 (antigen identified by monoclonal antibody Ki 67) [NCBI Gene 17345] {aka D630048A14Rik, Ki-67, Ki67}
- **Diseases:** skin neoplasm (MESH:D012878), pancreatic and breast cancer (MESH:D001943), cancer (MESH:D009369), Melanoma (MESH:D008545), metastases (MESH:D009362)
- **Chemicals:** Vem (MESH:D014213), CCG-257081 (-), vemurafenib (MESH:D000077484), ROS (MESH:D017382)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** YUMMER_P — Mus musculus (Mouse), Mouse melanoma, Cancer cell line (CVCL_A2AX)

## Full text

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## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12308238/full.md

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Source: https://tomesphere.com/paper/PMC12308238