# Comment on ‘Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis’ by Espino‐Guarch et al

**Authors:** Jinglin Li, Jiachen Peng

PMC · DOI: 10.1002/jcsm.70037 · Journal of Cachexia, Sarcopenia and Muscle · 2025-07-30

## Full-text entities

- **Genes:** Rps6kb1 (ribosomal protein S6 kinase B1) [NCBI Gene 72508] {aka 2610318I15Rik, P70S6K1, S6K, S6K-beta-1, S6K1, p70 S6K-alpha}, Lat2 (linker for activation of T cells family, member 2) [NCBI Gene 56743] {aka LAB, NTAL, WSCR5, Wbscr15, Wbscr5}, Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac}, Trim63 (tripartite motif-containing 63) [NCBI Gene 433766] {aka MuRF1, RF1, Rnf28}, Tsc22d1 (TSC22 domain family, member 1) [NCBI Gene 21807] {aka Egr5, Gm19597, TSC-22, Tgfb1i4, Tsc, Tsc22}, Fgf21 (fibroblast growth factor 21) [NCBI Gene 56636] {aka Fgf8c}, Rheb (Ras homolog enriched in brain) [NCBI Gene 19744] {aka Rheb1}, Eif4ebp1 (eukaryotic translation initiation factor 4E binding protein 1) [NCBI Gene 13685] {aka 4e-bp1, PHAS-I}, Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) [NCBI Gene 18033] {aka NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105}, Fbxo32 (F-box protein 32) [NCBI Gene 67731] {aka 4833442G10Rik, ATROGIN1, Gm20361, MAFbx}, Tnf (tumor necrosis factor) [NCBI Gene 21926] {aka DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa}, Il6 (interleukin 6) [NCBI Gene 16193] {aka Il-6}, Slc3a2 (solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2) [NCBI Gene 17254] {aka 4F2, 4F2HC, Cd98, Ly-10, Ly-m10, Ly10}, Ulk1 (unc-51 like kinase 1) [NCBI Gene 22241] {aka Unc51.1, mKIAA0722}, Stat3 (signal transducer and activator of transcription 3) [NCBI Gene 20848] {aka 1110034C02Rik, Aprf}, LAT2 (linker for activation of T cells family member 2) [NCBI Gene 7462] {aka HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5}
- **Diseases:** mitochondrial dysfunction (MESH:D028361), atrophy (MESH:D001284), T1D (MESH:D003922), cancer cachexia (MESH:D009369), inflammation (MESH:D007249), sarcopenia (MESH:D055948), muscle wasting (MESH:D009133), insulin deficiency (MESH:D007333)
- **Chemicals:** Gln (MESH:D005973), Bargain (-), spermidine (MESH:D013095), ketone bodies (MESH:D007657), ATP (MESH:D000255), amino acid (MESH:D000596), rapamycin (MESH:D020123), free fatty acids (MESH:D005230)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12308211/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12308211/full.md

---
Source: https://tomesphere.com/paper/PMC12308211