# An unusual distal tibial metastasis from urothelial carcinoma: A case report

**Authors:** Tran Ngoc An Huynh, Darren Trinh, Janan Chandrananth, James Sewell

PMC · DOI: 10.14440/bladder.2024.0077 · Bladder · 2025-03-21

## TL;DR

This case report describes a rare instance of bladder cancer spreading to the tibia, highlighting the importance of considering unusual metastatic locations.

## Contribution

The report presents a rare case of distal tibial metastasis from urothelial carcinoma, expanding the known patterns of cancer spread.

## Key findings

- Bladder cancer metastasized to the distal tibia in an 84-year-old patient.
- Surgical fixation and radiotherapy were used to manage the metastasis.
- Unusual bone metastasis locations should be considered in cancer patients with unexplained bone pain.

## Abstract

Bladder cancer (BCa) frequently metastasizes to bones, typically affecting the spine and pelvis.

Presented here is a case of rare extensive distal tibia metastasis in an 84-year-old female with invasive high-grade urothelial carcinoma, who suffered from rapidly progressive ankle pain and reduced mobility. Imaging and biopsy confirmed metastatic urothelial carcinoma in the tibia, which was managed with surgical fixation and palliative radiotherapy. Although bone metastases in BCa commonly affect other sites, clinicians should consider atypical locations like the tibia in patients with unexplained bone pain.

Early diagnosis and intervention are essential for improving patient outcomes and quality of life.

## Linked entities

- **Diseases:** bladder cancer (MONDO:0004986), urothelial carcinoma (MONDO:0040679)

## Full-text entities

- **Diseases:** bone metastases (MESH:D009362), ankle pain (MESH:D010146), urothelial carcinoma (MESH:D014523), BCa (MESH:D001749)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12308123/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12308123/full.md

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Source: https://tomesphere.com/paper/PMC12308123