This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: Calycosin Inhibits Hepatocyte Apoptosis in Acute Liver Failure by Suppressing the TLR4/NF‐κB Pathway: An In Vitro Study
TL;DR
This retracted study claimed that calycosin reduces liver cell death in acute liver failure by blocking a specific pathway, but concerns about data inconsistencies led to its retraction.
Contribution
The paper originally proposed a novel mechanism for calycosin's protective effects in liver failure via the TLR4/NF-κB pathway.
Findings
Calycosin was reported to inhibit hepatocyte apoptosis in acute liver failure.
The TLR4/NF-κB pathway was suggested as a key target for calycosin's protective effects.
Abstract
RETRACTION: L. Chang, A. Zhang, W. Liu, P. Cao, L. Dong, and X. Gao, “Calycosin Inhibits Hepatocyte Apoptosis in Acute Liver Failure by Suppressing the TLR4/NF‐κB Pathway: An In Vitro Study,” Immunity, Inflammation and Disease 11, no. 7 (2023): e935, https://doi.org/10.1002/iid3.935. The above article, published online on July 12, 2023, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons, Ltd. The retraction was agreed upon following an investigation into concerns raised by a third party regarding unexpected similarity between the flow cytometry data in Figure 2C of this article and data published earlier in a separate article by a different group of authors. Inconsistencies were also observed in the western blot presented in Figure 5A of this article. The authors provided supporting…
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Taxonomy
TopicsDrug-Induced Hepatotoxicity and Protection · Pharmacological Effects of Natural Compounds · Traditional Chinese Medicine Analysis
RETRACTION: L. Chang, A. Zhang, W. Liu, P. Cao, L. Dong, and X. Gao, “Calycosin Inhibits Hepatocyte Apoptosis in Acute Liver Failure by Suppressing the TLR4/NF‐κB Pathway: An In Vitro Study,” Immunity, Inflammation and Disease 11, no. 7 (2023): e935, https://doi.org/10.1002/iid3.935.
The above article, published online on July 12, 2023, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons, Ltd. The retraction was agreed upon following an investigation into concerns raised by a third party regarding unexpected similarity between the flow cytometry data in Figure 2C of this article and data published earlier in a separate article by a different group of authors. Inconsistencies were also observed in the western blot presented in Figure 5A of this article. The authors provided supporting data for the flow cytometry plots in Figures 2C and 7C; however, the data did not align with the figures presented in the published article. Additionally, they did not address or provide any data in response to concerns regarding the western blot. Given these issues and the lack of adequate supporting data, the editors find the article's results and conclusions to be unreliable. The authors were informed of the decision to retract but did not respond to requests for comment.