# Three-Dimensional visualization reconstruction assisted in the treatment of retroperitoneal liposarcoma: a case report

**Authors:** Xiangxiang Ren, Tianhao Xie, Litao Liu, Xiaoshi Jin, Meng Zhang

PMC · DOI: 10.3389/fsurg.2025.1609274 · Frontiers in Surgery · 2025-07-16

## TL;DR

This case report shows how 3D visualization helped surgeons plan and successfully remove a complex retroperitoneal liposarcoma with no recurrence after six months.

## Contribution

Demonstrates the clinical utility of 3DVR in surgical planning for complex retroperitoneal liposarcoma.

## Key findings

- 3D reconstruction enabled precise preoperative simulation of en bloc resection and splenectomy.
- Gross total resection (R0) was achieved with no splenic invasion confirmed.
- 3DVR improved stereoscopic assessment and reduced intraoperative uncertainty compared to 2D imaging.

## Abstract

To evaluate the clinical efficacy of three-dimensional visualization reconstruction (3DVR) in surgical planning for complex retroperitoneal liposarcoma (RLS), we report a case of a 64-year-old female patient presenting with a mass posterior to the spleen. CT/MRI revealed a retro-splenic mass, later pathologically confirmed as dedifferentiated liposarcoma. 3D reconstruction precisely delineated a 12 × 6.0 cm tumor with three splenic feeding vessels, enabling preoperative simulation of an en bloc resection combined with splenectomy. Gross total resection (R0 resection) was achieved, and pathology confirmed no splenic invasion. No recurrence was observed during 6-month follow-up.

Compared to 2D imaging, 3D reconstruction improved stereoscopic assessment of tumor-vessel-organ relationships, reducing intraoperative uncertainty. Challenges in retroperitoneal soft-tissue contrast were mitigated using advanced segmentation. The technique enhances surgical precision, lowers operative risks, and may improve recurrence-free survival. Integration with virtual reality could further optimize preoperative planning, advocating its adoption in complex abdominal oncology.

## Linked entities

- **Diseases:** dedifferentiated liposarcoma (MONDO:0020563)

## Full-text entities

- **Genes:** Mdm2 (MDM2 proto-oncogene) [NCBI Gene 17246] {aka 1700007J15Rik, Mdm-2}, Mki67 (antigen identified by monoclonal antibody Ki 67) [NCBI Gene 17345] {aka D630048A14Rik, Ki-67, Ki67}, Cd34 (CD34 antigen) [NCBI Gene 12490], Erg (ETS transcription factor) [NCBI Gene 13876] {aka D030036I24Rik}, Cdkn2a (cyclin dependent kinase inhibitor 2A) [NCBI Gene 12578] {aka ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1}, Epcam (epithelial cell adhesion molecule) [NCBI Gene 17075] {aka CD326, EGP, EGP-2, Egp314, Ep-CAM, EpCAM1}, Cdk4 (cyclin dependent kinase 4) [NCBI Gene 12567] {aka Crk3}, Cd68 (CD68 antigen) [NCBI Gene 12514] {aka Lamp4, Scard1, gp110}, Calb2 (calbindin 2) [NCBI Gene 12308] {aka CR}
- **Diseases:** abdominal distension (MESH:D000007), ascites (MESH:D001201), mesenchymal tumor (MESH:C535700), dedifferentiated liposarcoma (MESH:D008080), calcification (MESH:D002114), rebound tenderness (MESH:D063806), blood loss (MESH:D016063), muscle rigidity (MESH:D009127), bleeding (MESH:D006470), RLS (MESH:C538370), hemoperitoneum (MESH:D006465), Tumor (MESH:D009369), retroperitoneal malignancies (MESH:D012186), blood (MESH:D006402)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12307391/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12307391/full.md

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Source: https://tomesphere.com/paper/PMC12307391