# Electrical alternans of the Q-T interval and fatal arrhythmias caused by neonatal cardiac tumor: a case report

**Authors:** Ge Wang, Jin Ding, Hongguang Wu, Yanhong Chen, Xiaoqi Deng, Hairui Li, Haiying Li

PMC · DOI: 10.3389/fcvm.2025.1552916 · Frontiers in Cardiovascular Medicine · 2025-07-16

## TL;DR

A neonate with a cardiac tumor developed fatal arrhythmias, highlighting the severe risks of such tumors in newborns.

## Contribution

This case report presents a rare instance of fatal arrhythmias caused by a neonatal cardiac tumor.

## Key findings

- A neonate with a cardiac tumor developed fatal malignant arrhythmias.
- Electrocardiogram findings included ST-T changes and conduction blocks.
- Despite treatment, the neonate experienced sudden cardiac death.

## Abstract

Primary cardiac tumors in the fetal and neonatal populations are rare. In neonates, these tumors may present with a range of clinical manifestations, from asymptomatic cases to severe arrhythmias, valvular obstruction, and cardiac dysfunction. This report describes a case of fatal malignant arrhythmia caused by a cardiac tumor in an 8-day-old neonate. The electrocardiogram at birth revealed multiple abnormalities, including ST-T segment alterations, intraventricular conduction block, and bundle branch block. By the sixth postnatal day, the patient developed rapid, polymorphic malignant ventricular arrhythmias. Despite aggressive treatment, the neonate ultimately suffered sudden cardiac death. This case underscores the potentially fatal risk of arrhythmias associated with cardiac tumors.

## Linked entities

- **Diseases:** cardiac tumor (MONDO:0001340)

## Full-text entities

- **Genes:** TSC1 (TSC complex subunit 1) [NCBI Gene 7248] {aka LAM, TSC}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}
- **Diseases:** valve malformations (MESH:D006349), cardiac dysfunction (MESH:D006331), hypercholesterolemia (MESH:D006937), Hemangiomas (MESH:D006391), edema (MESH:D004487), metabolic disturbances (MESH:D024821), lymphoma (MESH:D008223), tumor lysis syndrome (MESH:D015275), sudden cardiac death (MESH:D016757), Q-T (MESH:D001260), angiosarcomas (MESH:D006394), intraventricular conduction block (MESH:D006327), pancreatic impairment (MESH:D010195), Arrhythmias (MESH:D001145), coronary abnormalities (MESH:D003327), dead (MESH:D001926), cardiac distress (MESH:D012128), thrombocytopenia (MESH:D013921), gastrointestinal bleeding (MESH:D006471), intraventricular block (MESH:D006345), necrotizing enterocolitis (MESH:D020345), ventricular premature beats (MESH:D018879), infection (MESH:D007239), anuria (MESH:D001002), LCOS (MESH:D002303), multiorgan failure (MESH:D051437), hypotension (MESH:D007022), lipomas (MESH:D008067), atrial tumor (MESH:D009369), Cardiac tumors (MESH:D006338), SVT (MESH:D013617), glucose intolerance (MESH:D018149), hypertriglyceridemia (MESH:D015228), bundle branch block (MESH:D002037), cardiac death (MESH:D003643), WPW (MESH:D014927), Rhabdomyomas (MESH:D012207), genetic syndromes (MESH:D030342), proteinuria (MESH:D011507), necrotic (MESH:D009336), cardiogenic shock (MESH:D012770), torsade de pointes (MESH:D016171), pulmonary artery sarcomas (MESH:D000071079), leukopenia (MESH:D007970), anemia (MESH:D000740), Cardiac myxomas (MESH:D009232), shock (MESH:D012769), pericardial effusion (MESH:D010490), cystic tumor (MESH:D018297), nerve damage (MESH:D000080902), sudden neonatal death (MESH:D003645), tachyarrhythmias (MESH:D013610), R-on-T phenomenon (MESH:C580424), arrhythmic (OMIM:212500), diabetes mellitus (MESH:D003920), bleeding (MESH:D006470), AVB (MESH:D054537), systemic embolism (MESH:D004617), papillary fibroelastomas (MESH:D000084122), prolapse (MESH:D011391)
- **Chemicals:** lactic acid (MESH:D019344), amiodarone (MESH:D000638), cyclosporin (MESH:D016572), epinephrine (MESH:D004837), esmolol (MESH:C036604), lidocaine (MESH:D008012), Sirolimus (MESH:D020123), sodium bicarbonate (MESH:D017693), Magnesium sulfate (MESH:D008278), creatinine (MESH:D003404), simoros (-), everolimus (MESH:D000068338), macrolide (MESH:D018942)
- **Species:** Streptomyces hygroscopicus (species) [taxon 1912], Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12307388/full.md

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12307388/full.md

## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12307388/full.md

---
Source: https://tomesphere.com/paper/PMC12307388