# Case Report: A case series: heart rate variability during dental treatment with vasovagal reflex

**Authors:** Kaoru Yamashita, Toshiro Kibe, Shusei Yoshimine, Akari Uto, Minako Uchino, Mitsutaka Sugimura

PMC · DOI: 10.3389/fphys.2025.1607816 · Frontiers in Physiology · 2025-07-16

## TL;DR

This case report explores how monitoring heart rate variability during dental treatment can help prevent vasovagal reflexes by tracking autonomic nervous system activity.

## Contribution

The study introduces real-time autonomic monitoring to manage vasovagal reflexes during dental procedures.

## Key findings

- Parasympathetic hyperactivity followed by sympathetic hyperactivity was observed during vasovagal reflexes.
- Atropine sulfate hydrate reduced the high-frequency component and prevented vasovagal reflexes.
- Monitoring autonomic activity can improve dental treatment safety and comfort.

## Abstract

The vasovagal reflex is the most frequent emergency that occurs during dental procedures, but its underlying mechanism is not understood. In this study, we conducted autonomic monitoring of patients with a history of vasovagal reflexes.

We focused on the high-frequency component, an indicator of parasympathetic activity, and interrupted the treatment when the high-frequency component increased. Treatment was then resumed after confirming that there was no mood disturbance and no increase in the high-frequency component. In another patient with a history of dental treatment-induced vasovagal reflex, autonomic activity during treatment was measured under atropine sulfate hydrate administration.

Analysis of heart rate variability during the vasovagal reflex showed that parasympathetic hyperactivity was followed by sympathetic hyperactivity, indicating real-time changes in autonomic nervous system activity. In addition, the high-frequency component, which decreased after atropine sulfate hydrate administration, did not increase during treatment, along with the low-frequency to high-frequency ratio, a measure of sympathetic nervous system activity, and the vasovagal reflex did not occur. We believe that the visualization of a patient’s autonomic nervous system activity during dental treatment will improve the quality of systemic management and lead to the realization of a safe and comfortable treatment environment.

## Linked entities

- **Chemicals:** atropine sulfate hydrate (PubChem CID 517295)

## Full-text entities

- **Diseases:** dry mouth (MESH:D014987), incontinence (MESH:D014549), hyperactivity (MESH:D006948), TCR (MESH:D006331), vomiting (MESH:D014839), VVR (MESH:D019462), hypoglycemia (MESH:D007003), Anxiety (MESH:D001007), seizures (MESH:D012640), tachycardia (MESH:D013610), mood disturbance (MESH:D019964), pain (MESH:D010146), bradycardia (MESH:D001919), nausea (MESH:D009325), mandibular third molar (MESH:D008338), dental phobia (MESH:D010698), caries (MESH:D003731), HF (MESH:D006316), rigidity (MESH:D009127), syncope (MESH:D013575), loss of consciousness (MESH:D014474), extremities (MESH:C563475)
- **Chemicals:** propofol (MESH:D015742), nitrous oxide (MESH:D009609), lidocaine (MESH:D008012), Atropine (MESH:D001285), adrenaline (MESH:D004837), midazolam (MESH:D008874), TCR (-), oxygen (MESH:D010100), blood glucose (MESH:D001786)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12307358/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12307358/full.md

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Source: https://tomesphere.com/paper/PMC12307358