# Perforated Rectal Cancer Presenting With Symptoms of Sciatic Nerve Compression: A Case Report

**Authors:** J. L. O'Sullivan, L. Vu, P. Tan

PMC · DOI: 10.1155/cris/8680616 · Case Reports in Surgery · 2025-07-22

## TL;DR

This case report describes a rare instance of rectal cancer that spread to the sciatic nerve, causing leg pain and falls, highlighting diagnostic challenges.

## Contribution

The novelty lies in presenting an atypical clinical presentation of rectal cancer involving sciatic nerve compression.

## Key findings

- A case of locally advanced rectal cancer perforating into the greater sciatic notch was identified.
- The patient presented with lower limb pain and recurrent falls, mimicking sciatic nerve compression.
- The case emphasizes the difficulty in diagnosing unusual colorectal cancer presentations.

## Abstract

In this paper, we discuss the case of a late presentation, locally advanced rectal cancer that has perforated into the greater sciatic notch, presenting with symptoms of lower limb pain and recurrent falls. In this case, we discuss the complexities of diagnosing and managing atypical presentations of colorectal cancer.

## Linked entities

- **Diseases:** rectal cancer (MONDO:0006519), colorectal cancer (MONDO:0005575)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}
- **Diseases:** falls (MESH:C537863), infection (MESH:D007239), inflammation (MESH:D007249), Sciatic Nerve Compression (MESH:D009408), lipomas (MESH:D008067), cancer (MESH:D009369), adenocarcinoma (MESH:D000230), lower leg weakness (MESH:D018908), infectious (MESH:D003141), constipation (MESH:D003248), perforated (MESH:D057112), Rectal cancer (MESH:D012004), lumbosacral plexopathy (MESH:C537221), pressure sore (MESH:D003668), pain, sensory, and motor deficits (MESH:D013001), tenderness (MESH:D063806), necrosis (MESH:D009336), liver metastases (MESH:D009362), bowel obstruction (MESH:D012778), liver disease (MESH:D008107), sepsis (MESH:D018805), abscess (MESH:D000038), lower leg pain (MESH:D010146), gluteal abscess (MESH:C531783), weight loss (MESH:D015431), sciatic neuropathy (MESH:D020426), atrophy (MESH:D001284), Nerve sheath tumors (MESH:D018317), Perforated colon cancer (MESH:D015179), pelvic malignancies (MESH:D010386), DVT (MESH:D013927), erythema (MESH:D004890), paresthesia (MESH:D010292), induration (MESH:D010411), Antalgic gait (MESH:D020234), schwannomas (MESH:D009442)
- **Chemicals:** alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606], Escherichia coli (E. coli, species) [taxon 562]
- **Mutations:** V600E

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12307074/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12307074/full.md

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Source: https://tomesphere.com/paper/PMC12307074