# Editorial: Editor’s feature: negative findings in pharmacogenetics and pharmacogenomics volume II

**Authors:** José A. G. Agúndez, Elena García-Martín, Luis Abel Quiñones

PMC · DOI: 10.3389/fphar.2025.1658876 · Frontiers in Pharmacology · 2025-07-15

## Full-text entities

- **Genes:** ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit) [NCBI Gene 2068] {aka COFS2, CXPD, EM9, TFIIH, TTD, TTD1}, XRCC1 (X-ray repair cross complementing 1) [NCBI Gene 7515] {aka RCC, SCAR26}, NFATC2 (nuclear factor of activated T cells 2) [NCBI Gene 4773] {aka JCOSL, NFAT1, NFATP}, CYP3A4 (cytochrome P450 family 3 subfamily A member 4) [NCBI Gene 1576] {aka CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4}, MTHFR (methylenetetrahydrofolate reductase) [NCBI Gene 4524], GRIA1 (glutamate ionotropic receptor AMPA type subunit 1) [NCBI Gene 2890] {aka GLUH1, GLUR1, GLURA, GluA1, HBGR1, MRD67}, CYP3A5 (cytochrome P450 family 3 subfamily A member 5) [NCBI Gene 1577] {aka CP35, CYPIIIA5, P450PCN3, PCN3}, TYMS (thymidylate synthetase) [NCBI Gene 7298] {aka DKCD, HST422, TMS, TS}, ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit) [NCBI Gene 2067] {aka COFS4, RAD10, UV20}, DPYD (dihydropyrimidine dehydrogenase) [NCBI Gene 1806] {aka DHP, DHPDHASE, DPD, DYPD}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, NAT2 (N-acetyltransferase 2) [NCBI Gene 10] {aka AAC2, NAT-2, PNAT}, NR1H4 (nuclear receptor subfamily 1 group H member 4) [NCBI Gene 9971] {aka BAR, FXR, HRR-1, HRR1, PFIC5, RIP14}, ABCB1 (ATP binding cassette subfamily B member 1) [NCBI Gene 5243] {aka ABC20, CD243, CLCS, ENPAT, GP170, MDR1}, PPARA (peroxisome proliferator activated receptor alpha) [NCBI Gene 5465] {aka NR1C1, PPAR, PPAR-alpha, PPARalpha, hPPAR}, NR1I2 (nuclear receptor subfamily 1 group I member 2) [NCBI Gene 8856] {aka BXR, ONR1, PAR, PAR1, PAR2, PARq}, UGT1A1 (UDP glucuronosyltransferase family 1 member A1) [NCBI Gene 54658] {aka BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1}
- **Diseases:** toxicity (MESH:D064420), DBP (OMIM:261515), hypertension (MESH:D006973), pancreatitis (MESH:D010195), acute lymphoblastic leukemia (MESH:D054198), colorectal cancer (MESH:D015179), hyperbilirubinemia (MESH:D006932), Gilbert's syndrome (MESH:D005878), hypersensitivity (MESH:D004342)
- **Chemicals:** fluoropyrimidine (-), tacrolimus (MESH:D016559), FOLFOX (MESH:C410216), bilirubin (MESH:D001663)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** rs6889909, rs4958351, rs2229109, rs2242480, rs1128503, rs6021191, rs4986910
- **Cell lines:** SW480 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0546), SW620 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0547)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12306504/full.md

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Source: https://tomesphere.com/paper/PMC12306504