# Case Report: Iatrogenic intraperitoneal hematoma compresses the ureters leading to urogenic sepsis

**Authors:** Zhengyi Zhang, Peng Ding, Meijie Yang, Xiujuan Zhou, Kunlan Long

PMC · DOI: 10.3389/fmed.2025.1574196 · 2025-07-15

## TL;DR

A rare case shows how a post-surgery abdominal hematoma can compress ureters, leading to severe urinary infection and sepsis.

## Contribution

This case report highlights a rare iatrogenic complication linking vascular surgery to urogenic sepsis through ureteral compression.

## Key findings

- An iatrogenic retroperitoneal hematoma compressed the ureters, causing obstruction and urogenic sepsis.
- Emergency stent implantation resolved the obstruction and improved the patient's condition.
- Multidisciplinary collaboration is essential for managing such complex post-surgical complications.

## Abstract

Urogenic sepsis is a systemic inflammatory response syndrome triggered by infections of the genitourinary tract. It is characterized by complex etiology, atypical clinical symptoms, rapid disease progression, and difficulty in treatment, making it a focal point and challenge in clinical diagnosis and therapy. Although endovascular interventions are effective in treating conditions such as iliac artery thrombosis, they can also lead to complications such as arterial rupture and subsequent hematoma formation. This article reports a rare case of urogenic sepsis that developed secondary to urinary tract obstruction and infection caused by compression of the ureter due to an iatrogenic retroperitoneal hematoma following endovascular surgery.

A 63-year-old male patient was admitted to the hospital with symptoms of severe viral pneumonia and acute heart failure. Two months earlier, the patient had undergone a vascular interventional procedure, during which a rupture of the left iliac artery led to the formation of an intra-abdominal hematoma, a condition that was not given due attention at the time. Although initial treatment was provided for the respiratory and cardiac issues, the patient’s condition continued to deteriorate. Subsequent examinations revealed that the hematoma was compressing the ureters, causing severe ureteral obstruction and urinary sepsis. The patient then underwent an emergency transurethral ureteral stent implantation. Following the procedure, the patient’s condition significantly improved, and he was eventually discharged from the hospital.

Cases of iatrogenic intraperitoneal hematoma compressing the ureters and subsequently causing urogenic sepsis are extremely rare in clinical practice. This case highlights the necessity of early identification and intervention of iatrogenic complications, especially in the patient population with a history of vascular interventional surgery. It underscores the crucial role of targeted diagnostic strategies and surgical interventions in resolving the challenge of mechanical obstruction. The research findings indicate that it is essential to establish a multidisciplinary collaborative mechanism to effectively manage such complex cases.

## Linked entities

- **Diseases:** viral pneumonia (MONDO:0006012)

## Full-text entities

- **Genes:** TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, LCN2 (lipocalin 2) [NCBI Gene 3934] {aka 24p3, MSFI, NGAL, p25}, CALCA (calcitonin related polypeptide alpha) [NCBI Gene 796] {aka CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT}, HAVCR1 (hepatitis A virus cellular receptor 1) [NCBI Gene 26762] {aka CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM}
- **Diseases:** tract (MESH:D014570), Complicated urinary tract infections (MESH:D014552), Hematoma (MESH:D006406), reperfusion injury (MESH:D015427), abdominal pain (MESH:D015746), respiratory failure (MESH:D012131), ureteral compression (MESH:D014515), ureteral stricture (MESH:D003251), detrusor dysfunction (MESH:D053201), Ureteral obstruction (MESH:D014517), hypoxemia (MESH:D000860), renal dysfunction (MESH:D007674), morphological abnormalities (MESH:D000013), renal tubulointerstitial fibrosis (OMIM:162000), postoperative complications (MESH:D011183), aortic thrombosis (MESH:D013927), obstruction (MESH:D000402), bleeding (MESH:D006470), diabetes mellitus (MESH:D003920), septic shock (MESH:D012772), organ dysfunction (MESH:D009102), pleural effusion (MESH:D010996), ischemia (MESH:D007511), trauma (MESH:D014947), dyspnea (MESH:D004417), glomerulosclerosis (MESH:D005921), Arterial rupture (MESH:D012421), acute heart failure (MESH:D006333), Chronic kidney disease (MESH:D051436), intra-abdominal hemorrhage (MESH:D000082122), Sepsis (MESH:D018805), pneumonia (MESH:D011014), lung infection (MESH:D012141), obstructive pyelonephritis (MESH:D011704), postoperative (MESH:D019106), cardiovascular diseases (MESH:D002318), cough (MESH:D003371), atrial fibrillation (MESH:D001281), obstructive uropathy (MESH:C536483), lower extremity artery thrombosis (MESH:D002341), urinary retention (MESH:D016055), hydronephrosis (MESH:D006869), metabolic acidosis (MESH:D000138), PD (MESH:D010300), Hydrops (MESH:D004487), acute kidney injury (MESH:D058186), metabolic abnormalities (MESH:D008659), infection (MESH:D007239), inflammatory (MESH:D007249), compression (MESH:D009408), iliac artery (MESH:D017543), renal failure (MESH:D051437), end-stage renal disease (MESH:D007676), tumor (MESH:D009369), Acute respiratory distress syndrome (MESH:D012128), genitourinary tract (MESH:C564424), Fibrosis (MESH:D005355), urine (MESH:D014555), bacteriuria (MESH:D001437)
- **Chemicals:** norepinephrine (MESH:D009638), ipratropium bromide (MESH:D009241), oxygen (MESH:D010100), furosemide (MESH:D005665), PO2:77.83 (-), Milrinone (MESH:D020105), reactive oxygen species (MESH:D017382), epinephrine (MESH:D004837), moxifloxacin (MESH:D000077266), oseltamivir (MESH:D053139), lactate (MESH:D019344), nitrite (MESH:D009573), budesonide (MESH:D019819), amiodarone (MESH:D000638)
- **Species:** Homo sapiens (human, species) [taxon 9606], Influenza A virus (H1N1) (no rank) [taxon 1323429]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12305811/full.md

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Source: https://tomesphere.com/paper/PMC12305811