# Association between acupuncture treatment exposure and mortality in patients with heart failure: a nationwide cohort study

**Authors:** Hyungsun Jun, Hanbit Jin, Haerim Kim, Jungtae Leem

PMC · DOI: 10.3389/fcvm.2025.1461302 · 2025-07-15

## TL;DR

A nationwide study in Korea found that acupuncture treatment within a year of heart failure diagnosis is linked to lower mortality rates.

## Contribution

This study provides empirical evidence of acupuncture's potential to reduce mortality in heart failure patients using nationwide claims data.

## Key findings

- Acupuncture exposure was associated with a 21% lower risk of circulatory disease-related mortality.
- Patients receiving acupuncture had a 27% lower risk of all-cause mortality.
- A dose-response relationship was observed, with more acupuncture sessions linked to greater mortality reduction.

## Abstract

Patients with heart failure (HF) require continuous management, creating a need for alternative treatments to reduce mortality. In Korea, acupuncture treatment is covered by national health insurance, offering accessible care without financial burden. Hence, this study utilized claims data from the Korean National Health Insurance Service to examine the association between acupuncture exposure and mortality in patients with HF.

Adults aged 20 years or older with newly diagnosed HF were included. Patients who received two or more acupuncture sessions within one year of diagnosis comprised the acupuncture treatment-exposed group (AT group), while those who received none were classified as the non-exposed group (non-AT group). Propensity score matching was used to generate a balanced 1:1 matched cohort. From one year after diagnosis, the study tracked circulatory and all-cause mortality over a five-year period, performing survival and dose-response analyses.

Each group included 4,315 patients, and the AT group showed significantly lower adjusted hazard ratios (aHRs) for circulatory disease-related mortality (0.79; 95% CI: 0.67–0.94) and all-cause mortality (0.73; 95% CI: 0.66–0.81). A clear dose-response relationship was observed, with greater exposure to acupuncture associated with lower aHRs.

Acupuncture within one year of HF diagnosis correlated with lower mortality from circulatory diseases and all causes. Future studies should adopt prospective and methodologically rigorous designs to validate the findings of this study.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252)

## Full-text entities

- **Genes:** REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}
- **Diseases:** death (MESH:D003643), diseases and injuries (MESH:D004194), cardiovascular conditions (MESH:D002318), myocardial ischemia (MESH:D017202), vascular dysfunction (MESH:D002561), circulatory disease (MESH:D012769), congestive (MESH:D002311), cardiac allograft vasculopathy (MESH:D006331), stroke (MESH:D020521), chronic pain (MESH:D059350), cardiac arrest (MESH:D006323), ischemic stroke (MESH:D002544), COPD (MESH:D029424), infections (MESH:D007239), hypotension (MESH:D007022), inflammation (MESH:D007249), cancer (MESH:D009369), acute myocardial infarction (MESH:D009203), hyperkalemia (MESH:D006947), peripheral artery disease (MESH:D058729), hypertension (MESH:D006973), dyslipidemia (MESH:D050171), functional disturbances (MESH:D003291), diabetes mellitus (MESH:D003920), renal impairment (MESH:D007674), cardiac abnormality (MESH:D018376), HF (MESH:D006333), organ dysfunction (MESH:D009102), pulmonary or systemic congestion (MESH:D001261)
- **Chemicals:** AT (MESH:D001246), nitric oxide (MESH:D009569), CC (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12305702/full.md

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Source: https://tomesphere.com/paper/PMC12305702